Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation

Objective Transcriptomic analysis of gene expression in brown adipose tissue (BAT) from mice in response to cold revealed strong induction of growth and differentiation factor 15 (GDF15). This study aimed to characterize GDF15 as a brown adipokine released in response to thermogenic activation and to determine its target functions. Methods GDF15 expression was measured in adipose tissues from mice in response to physiological and pharmacological...