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Francesc Villarroya
University of Barcelona
144Publications
40H-index
5,738Citations
Publications 144
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#1Joan Villarroya (University of Barcelona)H-Index: 17
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 6 authors...
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#1Tania Quesada-López (University of Barcelona)H-Index: 5
#2Aleix Gavaldà-Navarro (University of Barcelona)H-Index: 10
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 7 authors...
Adaptive induction of thermogenesis in brown adipose tissue (BAT) is essential for the survival of mammals after birth. We show here that G protein-coupled receptor protein 120 (GPR120) expression ...
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#1Laura Campderrós (University of Barcelona)H-Index: 1
#2Ricardo Moure (University of Barcelona)H-Index: 3
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 9 authors...
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#1Gemma Ferrer‐Curriu (University of Barcelona)
#2Ibon Redondo-Angulo (University of Barcelona)H-Index: 2
Last.Anna Planavila (University of Barcelona)H-Index: 3
view all 10 authors...
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#1Montserrat Cairó (University of Barcelona)H-Index: 5
#2Laura Campderrós (University of Barcelona)H-Index: 1
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 9 authors...
Abstract Parkin is an ubiquitin‐E3 ligase that acts as a key component of the cellular machinery for mitophagy. We show here that Parkin expression is reciprocally regulated in brown adipose tissue in relation to thermogenic activity. Thermogenic stimuli repress Parkin gene expression via transcriptional mechanisms that are elicited by noradrenergic and PPARα‐mediated pathways that involve intracellular lipolysis in brown adipocytes. Parkin‐KO mice show over‐activated brown adipose tissue thermo...
2 CitationsSource
#1Joan Villarroya (University of Barcelona)H-Index: 17
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 4 authors...
Background. The secretory properties of brown adipose tissue are thought to contribute to the association between active brown fat and a healthy metabolic status. Although a few brown adipokines have been identified, a comprehensive knowledge of the brown adipose tissue secretome is lacking. Methods. Here, to examine the effects of thermogenic activation of brown adipocytes on protein secretion, we used isobaric tags for relative and absolute quantification (iTRAQ) analysis to determine how the ...
1 CitationsSource
#1I. R. Ipharraguerre (CAU: University of Kiel)H-Index: 8
#2J. J. PastorH-Index: 3
Last.Alessandro MereuH-Index: 4
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The spread of bacterial resistance to antimicrobials (AMA) have intensified efforts to discontinue the non-therapeutic use of AMA in animal production. Finding alternatives to AMA, however, is currently encumbered by the obscure mechanism that underlies their growth-promoting action. In this report, we demonstrate that combinations of antibiotics and zinc oxide at doses commonly used for stimulating growth or preventing post-weaning enteritis in pigs converge in promoting microbial production of...
3 CitationsSource
#1Rubén Cereijo (University of Barcelona)H-Index: 11
#2Aleix Gavaldà-Navarro (University of Barcelona)H-Index: 10
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 14 authors...
Summary The beneficial effects of brown adipose tissue (BAT) are attributed to its capacity to oxidize metabolites and produce heat, but recent data suggest that secretory properties of BAT may also be involved. Here, we identify the chemokine CXCL14 (C-X-C motif chemokine ligand-14) as a novel regulatory factor secreted by BAT in response to thermogenic activation. We found that the CXCL14 released by brown adipocytes recruited alternatively activated (M2) macrophages. Cxcl14 -null mice exposed...
12 CitationsSource
#1Joan Villarroya (University of Barcelona)H-Index: 17
#2José M. Gallego-Escuredo (University of Barcelona)H-Index: 14
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 10 authors...
2 CitationsSource
#1Joan Villarroya (University of Barcelona)H-Index: 17
#2Laura Campderrós (University of Barcelona)H-Index: 1
Last.Francesc Villarroya (University of Barcelona)H-Index: 40
view all 7 authors...
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