AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression
Abstract
ZNF322A is an oncogenic zinc-finger transcription factor. Our published results show that ZNF322A positively regulates transcription of alpha-adducin (ADD1) and cyclin D1 (CCND1) to promote tumorgenicity of lung cancer. However, the upstream regulatory mechanisms of ZNF322A protein function remain elusive. Here, we demonstrate that AKT could phosphorylate ZNF322A by in vitro kinase assay and cell-based mass spectrometry analysis. Overexpression...
Paper Details
Title
AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression
Published Date
Aug 9, 2019
Journal
Volume
38
Issue
41
Pages
6723 - 6736
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History