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I-Ying Kuo
National Cheng Kung University
Molecular biologyDNA methylationCarcinomaCancer researchBiology
10Publications
6H-index
93Citations
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Publications 11
Newest
#1Sheng-You Liao (NCKU: National Cheng Kung University)H-Index: 1
#2I-Ying Kuo (NCKU: National Cheng Kung University)H-Index: 6
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 8 authors...
ZNF322A is an oncogenic zinc-finger transcription factor. Our published results show that ZNF322A positively regulates transcription of alpha-adducin (ADD1) and cyclin D1 (CCND1) to promote tumorgenicity of lung cancer. However, the upstream regulatory mechanisms of ZNF322A protein function remain elusive. Here, we demonstrate that AKT could phosphorylate ZNF322A by in vitro kinase assay and cell-based mass spectrometry analysis. Overexpression of AKT promoted ZNF322A protein stability and trans...
1 CitationsSource
#1I-Ying Kuo (NCKU: National Cheng Kung University)H-Index: 6
#2Yu-Lin Huang (NCKU: National Cheng Kung University)H-Index: 2
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 7 authors...
Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biomarkers for predicting CCRT response is immensely important. In this study, we evaluated the predicting value of SRY (sex determining region Y)-box 17 (SOX17) protein during CCRT and its dysregulation of transcriptional targets in CCRT resistance in ESCC. Pyrosequencing methylation, RT-qPCR ...
2 CitationsSource
#1Shu-Huei Cho (NCKU: National Cheng Kung University)H-Index: 1
#2I-Ying Kuo (NCKU: National Cheng Kung University)H-Index: 6
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 7 authors...
Recent studies have revealed that dysregulated Rab small GTPase-mediated vesicle trafficking pathways are associated with cancer progression. However, whether any of the Rabs plays a suppressor role in cancer stemness is least explored. Rab37 has been postulated as a tumor suppressive small GTPase for trafficking anti-tumor cargos. Here, we report a previously uncharacterized mechanism by which Rab37 mediates exocytosis of secreted frizzled-related protein-1 (SFRP1), an extracellular antagonist ...
3 CitationsSource
#1Kuang-Tzu Huang (Memorial Hospital of South Bend)H-Index: 5
#2I-Ying Kuo (Memorial Hospital of South Bend)H-Index: 1
Last. Kuang-Den Chen (Memorial Hospital of South Bend)H-Index: 7
view all 13 authors...
Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies worldwide. Treatment outcomes remain poor mainly due to lack of good diagnostic/prognostic markers and limited therapeutic strategies. We previously characterized aberrant activation of the TF/FVII/PAR2 pathway, which subsequently results in decreased autophagy, as a crucial event in malignant progression of HCC. Here, we identified miR-135a as a highly upregulated miRNA in HCC in response to TF/FVII/PAR2 activa...
6 CitationsSource
#1Wei-Lun Chang (NCKU: National Cheng Kung University)H-Index: 18
#2Wu-Wei Lai (NCKU: National Cheng Kung University)H-Index: 23
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 7 authors...
Background Prognosis of esophageal squamous cell carcinoma (ESCC) patients remains poor, and the chemoradiotherapy (CRT) applied to ESCC patients often failed. Therefore, development of biomarkers to predict CRT response is immensely important for choosing the best treatment strategy of an individual patient.
6 CitationsSource
#1I-Ying Kuo (NCKU: National Cheng Kung University)H-Index: 6
#2Jayu Jen (NCKU: National Cheng Kung University)H-Index: 6
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 6 authors...
Background The incidence of lung adenocarcinoma (LUAD) is increasing worldwide with different prognosis even in early-stage patients. We aimed to identify a prognostic panel with multiple DNA methylation biomarkers to predict survival in early-stage LUAD patients of different racial groups.
3 CitationsSource
#1Kuang-Den ChenH-Index: 7
#2Kuang-Tzu HuangH-Index: 5
Last. Chih-Wen LinH-Index: 7
view all 9 authors...
In this invited News and Commentary article, we discuss our new paper ‘Factor VII promotes hepatocellular carcinoma progression through ERK–TSC signaling' in Cell Death Discovery (ref. 8). Coagulation factor VII (FVII) is engaged in the initiation of the extrinsic coagulation pathway by binding to tissue factor (TF), and both factors have been considered as alternative therapeutic targets in hemostatic disorders and specific types of cancer.1, 2 It is universally accepted that FVII is manufactur...
3 CitationsSource
#1Ruo-Chia Tseng (TCU: Tzu Chi University)H-Index: 1
#2Jia Ming Chang (NCKU: National Cheng Kung University)H-Index: 7
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 9 authors...
Introduction: SLIT2, a secreted protein, has been found to inac- tivate Cdc42 GTPase to modulate neural cell migration. However, alteration of SLIT2-mediated Cdc42 in terms of migration regulation remains undefined in esophageal squamous cell carcinoma (ESCC). Methods: We report here in ESCC cell, animal, and clinical models that SLIT2 acts as a migration suppressor and serves as a prognostic biomarker. Results: The immunohistochemistry data indicated that 31.8% (49 of 154) of tumors from ESCC p...
11 CitationsSource
#1Chung-Han Tsai (NCKU: National Cheng Kung University)H-Index: 1
#2Hung-Chi Cheng (NCKU: National Cheng Kung University)H-Index: 19
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 15 authors...
Rab-controlled trafficking pathways have been implicated in tumourigenesis. Here the authors show that Rab37 suppresses metastasis by regulating the exocytosis of tissue inhibitor of metalloproteinase 1 to repress matrix metalloproteinase 9 and represents a novel prognostic marker for lung cancer.
17 CitationsSource
#1I-Ying Kuo (NCKU: National Cheng Kung University)H-Index: 6
#2Ching-Chi Wu (NCKU: National Cheng Kung University)H-Index: 1
Last. Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 11 authors...
The transcriptional network of the SRY (sex determining region Y)-box 17 (SOX17) and the prognostic impact of SOX17 protein expression in human cancers remain largely unclear. In this study, we evaluated the prognostic effect of low SOX17 protein expression and its dysregulation of transcriptional network in esophageal squamous cell carcinoma (ESCC). Low SOX17 protein expression was found in 47.4% (73 of 154) of ESCC patients with predicted poor prognosis. Re-expression of SOX17 in ESCC cells ca...
26 CitationsSource
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