SA81ASSOCIATION OF WHOLE-GENOME AND NETRIN1 SIGNALING PATHWAY-DERIVED POLYGENIC RISK SCORES FOR MAJOR DEPRESSIVE DISORDER AND WHITE MATTER MICROSTRUCTURE IN UK BIOBANK

A recent study by Wang et al. (2016a) claims that the low-frequency variant NR1H3 p.Arg415Gln is sufficient to cause multiple sclerosis in certain individuals and determines a patient’s likelihood of primary progressive disease. We sought to replicate this finding in the International MS Genetics Consortium (IMSGC) patient collection, which is 13-fold larger than the collection of Wang et al. (2016a), but we find no evidence that this variant is...