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Yanni Zeng
University of Edinburgh
29Publications
6H-index
99Citations
Publications 29
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#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-infl...
3 CitationsSource
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read ‘paternal imprinting’ and should have read ‘maternal imprinting’. This has been corrected in both the PDF and HTML versions of the Article.
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#1Rosie M. Walker (Edin.: University of Edinburgh)H-Index: 9
Last.Kathryn L. EvansH-Index: 20
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INTRODUCTIONThe Apolipoprotein E (APOE) {varepsilon}4 allele is the strongest genetic risk factor for Alzheimers disease (AD), while the {varepsilon}2 allele confers protection. Previous studies report differential DNA methylation of APOE between {varepsilon}4 and {varepsilon}2 carriers but associations with epigenome-wide methylation are unknown.nnMETHODSThe EPIC array was used to identify methylation differences between AD-free APOE {varepsilon}4 (n=2469) and {varepsilon}2 (n=1108) carriers us...
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#1Ryan Langdon (UoB: University of Bristol)H-Index: 4
#2Rebecca C Richmond (UoB: University of Bristol)H-Index: 20
Last.Caroline L. Relton (UoB: University of Bristol)H-Index: 49
view all 21 authors...
Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, we conduct epigenome-wide association studies (EWAS) of these factors and ~3-year survival using Illumina Methylation EPIC blood DNA methylation profiles from 409 individuals in the Head and Neck 5000 (HN5000) study. CpG site associations below our multiple-testing threshold (PBonferroni
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#1Andrew Bretherick (Edin.: University of Edinburgh)H-Index: 5
#2Oriol Canela-Xandri (Edin.: University of Edinburgh)H-Index: 10
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
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Target identification remains a crucial challenge in drug development. To enable unbiased detection of proteins and pathways that have a causal role in disease pathogenesis or progression, we propose proteome-by-phenome Mendelian Randomisation (P 2 MR). We first detected genetic variants associated with plasma concentration of 249 proteins. We then used 64 replicated variants in two-sample Mendelian Randomisation to quantify evidence of a causal role for each protein across 846 phenotypes: this ...
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#2Kathryn L. EvansH-Index: 20
Last.Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
view all 14 authors...
#2Kathryn L. EvansH-Index: 20
Last.Mark J. Adams (Edin.: University of Edinburgh)H-Index: 24
view all 15 authors...
#1David M. Howard (Edin.: University of Edinburgh)H-Index: 10
#2Toni Clarke (Edin.: University of Edinburgh)H-Index: 4
Last.Andrew M. McIntosh (Edin.: University of Edinburgh)H-Index: 75
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Background Major Depressive Disorder (MDD) is a leading cause of disability worldwide with an estimated heritability of 37%. MDD is clinically heterogeneous and has frequently been shown to be comorbid with a variety of other conditions. Both of these factors have potentially confounded previous attempts to elucidate MDD's genetic architecture. To investigate causal heterogeneity within MDD we sought to identify genetic subgroups associated with other traits within MDD cases. Methods We examined...
1 CitationsSource
#1Miruna C. Barbu (Edin.: University of Edinburgh)H-Index: 5
#2Thalia C. Eley (Medical Research Council)H-Index: 56
Last.Jorge A. Quiroz (Edin.: University of Edinburgh)H-Index: 23
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Background: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous risk-ass...
3 CitationsSource
#1Miruna C. BarbuH-Index: 5
#2Yanni ZengH-Index: 6
Last.Heather C. WhalleyH-Index: 47
view all 13 authors...
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