Porous Se@SiO2 nanospheres attenuate cisplatin-induced acute kidney injury via activation of Sirt1

Cisplatin (CDDP) is the most commonly used chemotherapeutic drug and has an irreplaceable role in cancer treatment. However, CDDP-induced acute kidney injury (AKI) greatly limits its use. Abundant evidence has confirmed that apoptosis contributes to AKI caused by CDDP administration. The nanoparticle form of selenium, also known as [email protected] nanocomposites (NPs), has been proven to be a potential agent to prevent apoptotic cell death. In...