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Toxicology and Applied Pharmacology
IF
3.62
Papers
14603
Papers 14581
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Published on Jan 1, 2019in Toxicology and Applied Pharmacology 3.62
Fan Wang3
Estimated H-index: 3
,
Ruiling Wang + 1 AuthorsWanguang Chen2
Estimated H-index: 2
Abstract Triclosan (TCS) is a broad-spectrum antibacterial agent and has been widely used in a diversity of personal care products. However, recent studies suggest that TCS has some adverse effects, and some evidences suggest in vitro neurotoxicity and developmental neurotoxicity of embryos. There are currently few studies concerning the mechanisms of TCS induced late developmental neurotoxic effect. Therefore, we investigated effects of juvenile zebrafish ( Danio rerio ) exposure to TCS. Male j...
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Published on Mar 1, 2019in Toxicology and Applied Pharmacology 3.62
Zhenxian Lin (Ocean University of China), Xiaona Zhang7
Estimated H-index: 7
(Ocean University of China)
+ 1 AuthorsShaoguo Ru10
Estimated H-index: 10
(Ocean University of China)
Abstract Bisphenol S (BPS), exhibiting estrogenic activity, has been reported to promote cell proliferation in MCF-7 breast cancer cells; however, the underlying mechanism remains unclear. In this study, BPS (1–100 μM) significantly promoted cell proliferation in ERα positive MCF-7 cells, but not in ERα negative MDA-MB-231 or SK-BR-3 cells, confirming the important role of ERα in BPS-induced cell proliferation. Results of the flow cytometry analysis indicated that 10 μM BPS promoted MCF-7 prolif...
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Published on Feb 1, 2019in Toxicology and Applied Pharmacology 3.62
Dennis R. Carty1
Estimated H-index: 1
(University of California, Davis),
Zachary S. Miller (University of Mississippi)+ 3 AuthorsKristine L. Willett29
Estimated H-index: 29
(University of Mississippi)
Abstract While Δ 9 -tetrahydrocannabinol (THC) has been widely studied in the realm of developmental and reproductive toxicology, few studies have investigated potential toxicities from a second widely used cannabis constituent, cannabidiol (CBD). CBD is popularized for its therapeutic potential for reducing seizure frequencies in epilepsy. This study investigated developmental origins of health and disease (DOHaD) via multigenerational gene expression patterns, behavior phenotypes, and reproduc...
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Published on Feb 1, 2019in Toxicology and Applied Pharmacology 3.62
Erin P. Madeen3
Estimated H-index: 3
(Oregon State University),
Lisbeth K. Siddens14
Estimated H-index: 14
(Oregon State University)
+ 9 AuthorsTed Ognibene13
Estimated H-index: 13
(Lawrence Livermore National Laboratory)
Abstract Benzo[ a ]pyrene (BaP), is a known human carcinogen (International Agency for Research on Cancer (IARC) class 1). The remarkable sensitivity (zepto-attomole 14 C in biological samples) of accelerator mass spectrometry (AMS) makes possible, with de minimus risk, pharmacokinetic (PK) analysis following [ 14 C]-BaP micro-dosing of humans. A 46 ng (5 nCi) dose was given thrice to 5 volunteers with minimum 2 weeks between dosing and plasma collected over 72 h. [ 14 C]-BaP eq PK analysis gave...
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Published on Feb 1, 2019in Toxicology and Applied Pharmacology 3.62
Zhuojian Sun (Qingdao Agricultural University), Qiu Li (Qingdao Agricultural University)+ 7 AuthorsShuang Wu (Qingdao Agricultural University)
Abstract Klebsiella pneumoniae causes severe infections including pneumonia and sepsis and treatments are complicated by increased levels of antibiotic resistance. We have identified a flavonoid kaempferol-3- O -glucorhamnoside derived from the plant Thesium chinense Turcz that possessed potent anti-inflammatory effects in K. pneumoniae infected mice. Administration of kaempferol-3- O -glucorhamnoside before bacterial challenge effectively suppressed expression of the major inflammatory cytokine...
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Published on Jan 1, 2019in Toxicology and Applied Pharmacology 3.62
C. Behr2
Estimated H-index: 2
,
M. Slopianka + 7 AuthorsB. van Ravenzwaay16
Estimated H-index: 16
Abstract The bile acid-liver-gut microbiota axis plays an important role in the host's health. The gut microbiota has an impact on the bile acid pool, but also the bile acids themselves can influence the gut microbiota composition. In this study, six antibiotics from five different classes (i.e. lincosamides, glycopeptides, macrolides, fluoroquinolones, aminoglycosides) were used to modulate microbial communities of Wistar rats to elucidate changes in the bile acid metabolism and to identify key...
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Published on Jan 1, 2019in Toxicology and Applied Pharmacology 3.62
Sara Ranjbar2
Estimated H-index: 2
(Shiraz University of Medical Sciences),
Ruttiros Khonkarn1
Estimated H-index: 1
(Chiang Mai University)
+ 7 AuthorsOmidreza Firuzi24
Estimated H-index: 24
(Shiraz University of Medical Sciences)
Abstract Multidrug resistance (MDR) in cancer cells is often associated with overexpression of ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1) and breast cancer resistance protein (BCRP/ABCG2). Modulators of these transporters might be helpful in overcoming MDR. Moreover, exploiting collateral sensitivity (CS) could be another approach for efficient treatment of cancer. Twelve novel 5-oxo-hexahydroquinoline de...
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Published on Mar 1, 2019in Toxicology and Applied Pharmacology 3.62
Qian Wu (Nanjing Medical University), Shelly Odwin-DaCosta4
Estimated H-index: 4
(Johns Hopkins University)
+ 2 AuthorsWan-yee Tang (Johns Hopkins University)
Abstract Catechol- O -methyltransferase (COMT) acts as a ‘gate-keeper’ to prevent DNA damage during estrogen metabolism. Both experimental and epidemiological studies suggest the role of COMT in pathogenesis of human breast cancer (BCa). It was previously reported that inhibition of COMT enzyme activity in estradiol-treated human breast epithelial carcinoma-derived MCF-7 cells caused increased oxidative DNA damage and formation of mutagenic depurinating adducts. To improve our understanding of f...
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Published on Jan 1, 2019in Toxicology and Applied Pharmacology 3.62
Zhenping Chen3
Estimated H-index: 3
(University of Texas Medical Branch),
Jianhua Gu (Houston Methodist Hospital)+ 6 AuthorsPaul J. Boor31
Estimated H-index: 31
(University of Texas Medical Branch)
Abstract Hypertrophic scars (HS) limit movement, decrease quality of life, and remain a major impediment to rehabilitation from burns. However, no effective pharmacologic therapies for HS exist. Here we tested the in vitro anti-fibrotic effects of the novel chemical N-(2-aminoethyl) ethanolamine (AEEA) at non-toxic concentrations. Scanning electron microscopy showed that AEEA markedly altered the structure of the extracellular matrix (ECM) produced by primary dermal fibroblasts isolated from a H...
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