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Toxicology and Applied Pharmacology
IF
3.58
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14652
Papers 14687
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Published on Jul 1, 2019in Toxicology and Applied Pharmacology 3.58
Katherine Kuhns1
Estimated H-index: 1
(Johns Hopkins University),
Hernando Lopez-Bertoni3
Estimated H-index: 3
(Johns Hopkins University)
+ 1 AuthorsJoseph Bressler20
Estimated H-index: 20
(Johns Hopkins University)
Abstract Glioblastomas are the most aggressive of malignant brain cancers with a median patient survival of approximately 18 months. We recently demonstrated that Tet methylcytosine dioxygenase 1(TET1) is involved in cellular responses to ionizing radiation (IR) in glial-, glioblastoma-, and non-tumor-derived cells. This study used a lentiviral-mediated knockdown of TET1 to further dissect the contribution of TET1 to the DNA damage response in glial cell lines by evaluating its role in DNA repai...
Published in Toxicology and Applied Pharmacology 3.58
Caroline Pinto4
Estimated H-index: 4
(UH: University of Houston),
Ruixin Hao4
Estimated H-index: 4
(UH: University of Houston)
+ -3 AuthorsMaria Bondesson2
Estimated H-index: 2
(IU: Indiana University Bloomington)
Abstract The high volume production compound bisphenol A (BPA) is of environmental concern largely because of its estrogenic activity. Consequently, BPA analogues have been synthesized to be considered as replacement molecules for BPA. These analogues need to be thoroughly evaluated for their estrogenic activity. Here, we combined mechanism zebrafish-based assays to examine estrogenic and anti-estrogenic activities of BPA and two of its analogues, bisphenol AF (BPAF) and bisphenol C (BPC) in vit...
Published in Toxicology and Applied Pharmacology 3.58
Pablo Pánico3
Estimated H-index: 3
(UNAM: National Autonomous University of Mexico),
Adriana Juárez-Nájera (UNAM: National Autonomous University of Mexico)+ -3 AuthorsMaría Salazar Ana (UNAM: National Autonomous University of Mexico)
Abstract Exposure to arsenic is associated with increased risk of developing insulin resistance and type 2 diabetes. The proteases calpain-1 (CAPN1), calpain-2 (CAPN2) and calpain-10 (CAPN10) and their endogenous inhibitor calpastatin (CAST) regulate glucose uptake in skeletal muscle and adipocytes. We investigated whether arsenic disrupts GLUT1 trafficking and function through calpain inhibition, using lymphocytes as a cell model. Lymphocytes from healthy subjects were treated with 0.1 or 1 μM ...
Published in Toxicology and Applied Pharmacology 3.58
Jingfang Sun (CPU: China Pharmaceutical University), Ran Tao1
Estimated H-index: 1
(CPU: China Pharmaceutical University)
+ -3 AuthorsXiaobo Zhang7
Estimated H-index: 7
(CPU: China Pharmaceutical University)
Abstract TGFβ signaling plays an important role in orchestrating a favorable microenvironment for tumor cell growth and promoting epithelial–mesenchymal transition. As a conventional nonsteroidal anti-inflammation drugs, tolfenamic acid (TA) has been previously reported to exhibit anti-cancer activity. Herein, we investigated the effect of TA on TGFβ-mediated pro-metastatic activity and the underlying mechanisms in hepatocellular carcinoma (HCC). As a result, TA suppresses TGFβ-induced migration...
Published in Toxicology and Applied Pharmacology 3.58
Paulo Michel Pinheiro Ferreira20
Estimated H-index: 20
,
Kátia da Conceição Machado7
Estimated H-index: 7
+ -3 AuthorsMilena Botelho Pereira Soares36
Estimated H-index: 36
(FIOCRUZ: Oswaldo Cruz Foundation)
Abstract Arylacetamides are widely used as synthetic intermediates to obtain medicinal substances. This work evaluated in vitro antiproliferative activity of ten 2-Chloro-N-arylacetamides on human normal and cancer cells and detailed in vivo toxicological and anticancer investigations. Initially, cytotoxic colorimetric assays were performed using tumor lines, peripheral blood mononuclear cells (PBMC) and erythrocytes. Compounds 2, 3 and 4 were tested for acute toxicity (50, 150 and 300 mg/kg) an...
Published on Jul 1, 2019in Toxicology and Applied Pharmacology 3.58
Mi Ho Jeong2
Estimated H-index: 2
(SKKU: Sungkyunkwan University),
Ha Ryong Kim1
Estimated H-index: 1
(CUA: The Catholic University of America)
+ 1 AuthorsKyu Hyuck Chung18
Estimated H-index: 18
(SKKU: Sungkyunkwan University)
Abstract Polyhexamethylene guanidine phosphate (PHMG-p), an antimicrobial additive, was used as a humidifier disinfectant in Korea and caused severe lung injuries, including lung fibrosis, in hundreds of victims. As PHMG-p-induced lung fibrosis is different from that induced by known fibrogenic agents such as bleomycin, it is important to understand the molecular mechanisms underlying this effect. A recent study showed that epithelial-mesenchymal transition (EMT) could play key roles in PHMG-p-i...
Published in Toxicology and Applied Pharmacology 3.58
Miyoung Yoon13
Estimated H-index: 13
,
C. Ring + -3 AuthorsE AndersenMelvin69
Estimated H-index: 69
Abstract A previously published human PBPK model for manganese (Mn) in infants and children has been updated with Mn in drinking water as an additional exposure source. Built upon the ability to capture differences in Mn source-specific regulation of intestinal uptake in nursing infants who are breast-fed and formula-fed, the updated model now describes the bioavailability of Mn from drinking water in children of ages 0–18. The age-related features, including the recommended age-specific Mn diet...
Published in Toxicology and Applied Pharmacology 3.58
Xi Li2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University),
Qi Wang1
Estimated H-index: 1
(Nanjing Medical University)
+ -3 AuthorsSufang Wua (SJTU: Shanghai Jiao Tong University)
Abstract Cisplatin (CDDP) is the most commonly used chemotherapeutic drug and has an irreplaceable role in cancer treatment. However, CDDP-induced acute kidney injury (AKI) greatly limits its use. Abundant evidence has confirmed that apoptosis contributes to AKI caused by CDDP administration. The nanoparticle form of selenium, also known as Se@SiO2 nanocomposites (NPs), has been proven to be a potential agent to prevent apoptotic cell death. In this article, we established acute kidney injury mo...
Published in Toxicology and Applied Pharmacology 3.58
Amany El-Shahawy Abdel-Maged1
Estimated H-index: 1
,
Amany M. Gad3
Estimated H-index: 3
+ -3 AuthorsSamar S. Azab10
Estimated H-index: 10
(Ain Shams University)
Abstract Rheumatoid arthritis (RA) is a chronic and progressive autoimmune inflammatory disease associated with irreversible joint destruction that leads to permanent motor disability and compromised quality of life. However, the main cause of RA is still unknown though stimulation of immune system and cells plays pivotal role in disease development and progression. Ramucirumab (RAM) is the monoclonal antibody against VEGF- receptor. This study aimed to investigate and evaluate the therapeutic e...
Published in Toxicology and Applied Pharmacology 3.58
Roman Mezencev (EPA: United States Environmental Protection Agency), Ravi P. Subramaniam10
Estimated H-index: 10
(EPA: United States Environmental Protection Agency)
Abstract High throughput screening (HTS) and functional genomics (toxicogenomics) have opened new avenues in toxicity testing. Their advantages include the potential for developing short-term in vivo bioassays and in vitro assays in order to keep pace with the growing backlog of chemicals that need to be evaluated for potential human health risk. In addition, these approaches have the potential to address some of the difficulties that arise with interpreting traditional rodent bioassays, such as...
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