Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept

The neuroprotective benefit of therapeutic hypothermia (TH) has been demonstrated, but systemic side effects and time required to achieve effective TH in acute ischemic stroke (AIS) care limits clinical use. We investigate rapid and localized cooling using a novel insulated catheter in an ischemia-reperfusion model.In phase I (n=4), cold saline was delivered to the canine internal carotid artery via an insulated catheter. Temperature was...