Original paper

A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

Volume: 9, Issue: 1
Published: Jul 29, 2019
Abstract
The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras binding to the Ras binding domain (RBD) of Raf. We recently reported that all-trans retinoic acid (atRA) rapidly (within minutes) activates Erk1/2 to modulate cell cycle...
Paper Details
Title
A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1
Published Date
Jul 29, 2019
Volume
9
Issue
1
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