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Sung Wook Park
University of Minnesota
Chromatin immunoprecipitationMolecular biologyChromatin remodelingChromatinBiology
25Publications
15H-index
539Citations
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Publications 26
Newest
#1Yi Wei Lin (UMN: University of Minnesota)H-Index: 11
#2Sung Wook Park (UMN: University of Minnesota)H-Index: 15
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 5 authors...
Obesity, an emerging global health issue, involves numerous factors; understanding its underlying mechanisms for prevention and therapeutics is urgently needed. Cellular retinoic acid binding protein 1 (Crabp1) knockout (CKO) mice exhibit an obese phenotype under normal diet (ND) feedings, which prompted us to propose that Crabp1 could play a role in modulating adipose tissue development/homeostasis. Studies were designed to elucidate the underlying mechanism of Crabp1′s action in reducing obesi...
Source
#1Sung Wook Park (UMN: University of Minnesota)H-Index: 15
#2Jennifer Nhieu (UMN: University of Minnesota)H-Index: 1
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 10 authors...
Source
#1Yi Wei Lin (UMN: University of Minnesota)H-Index: 11
#2Sung Wook Park (UMN: University of Minnesota)H-Index: 15
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 5 authors...
Source
#1Sung Wook Park (UMN: University of Minnesota)H-Index: 15
#2Jennifer Nhieu (UMN: University of Minnesota)H-Index: 1
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 4 authors...
Abstract Inhibiting Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) over activation can decrease detrimental cardiac remodeling that leads to dilated cardiomyopathy, cell death, and heart failure. We previously showed that cellular retinoic acid binding protein 1 (Crabp1) knockout mice (CKO) exhibited a more severe isoproterenol (ISO)-induced heart failure and cardiac remodeling phenotype with elevated CaMKII activity in the heart, suggesting a cardiac-protective function of Crabp1 throug...
1 CitationsSource
#1Sung Wook Park (UMN: University of Minnesota)H-Index: 15
#2Jennifer Nhieu (UMN: University of Minnesota)H-Index: 1
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 10 authors...
The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras binding to the Ras binding domain (RBD) of Raf. We recently reported that all-trans retinoic acid (atRA) rapidly (within minutes) activates Erk1/2 to modulate cell cycle progression in stem cells, which is mediated by cellular re...
Source
#1Sung Wook ParkH-Index: 15
#2Shawna D. Persaud (UMN: University of Minnesota)H-Index: 8
Last. Li-Na WeiH-Index: 39
view all 6 authors...
6 CitationsSource
#1Bomi Lee (UMN: University of Minnesota)H-Index: 4
#2Cheng-Ying Wu (UMN: University of Minnesota)H-Index: 6
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 5 authors...
All-trans Retinoic acid (RA) and its derivatives are potent therapeutics for immunological functions including wound repair. However, the molecular mechanism of RA modulation in innate immunity is poorly understood, especially in macrophages. We found that topical application of RA significantly improves wound healing and that RA and IL-4 synergistically activate Arg1, a critical gene for tissue repair, in M2 polarized macrophages. This involves feed forward regulation of Raldh2, a rate-limiting...
5 CitationsSource
#1Shawna D. Persaud (UMN: University of Minnesota)H-Index: 8
#2Sung Wook Park (UMN: University of Minnesota)H-Index: 15
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 6 authors...
All trans retinoic acid (atRA) is one of the most potent therapeutic agents, but extensive toxicity caused by nuclear RA receptors (RARs) limits its clinical application in treating cancer. AtRA also exerts non-genomic activities for which the mechanism remains poorly understood. We determine that cellular retinoic acid binding protein 1 (Crabp1) mediates the non-genomic activity of atRA, and identify two compounds as the ligands of Crabp1 to rapidly and RAR-independently activate extracellular ...
18 CitationsSource
#1Shawna D. Persaud (UMN: University of Minnesota)H-Index: 8
#2Wei Hong Huang (UMN: University of Minnesota)H-Index: 3
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 4 authors...
Receptor interacting protein 140 (RIP140) is a coregulator for numerous nuclear receptors and transcription factors and primarily exerts gene-repressive activities on various target genes. We previously identified a spectrum of posttranslational modifications on RIP140 that augment its property and biological activity. In T3-triggered biphasic regulation of cellular retinoic acid binding protein 1 (Crabp1) gene along the course of fibroblast-adipocyte differentiation, we found TRAP220(MED1) crit...
9 CitationsSource
#1Ya Shan Chuang (UMN: University of Minnesota)H-Index: 3
#2Wei Hong Huang (UMN: University of Minnesota)H-Index: 3
Last. Li-Na Wei (UMN: University of Minnesota)H-Index: 39
view all 7 authors...
Promyelocytic leukemia (Pml) protein is required for Oct4 gene expression and the maintenance of its open chromatin conformation in stem cells. In proliferating stem cells, Pml-nuclear body, along with transcription factors TR2, SF1 and Sp1 and Brg1-dependent chromatin remodeling complex (BRGC), associates with conserved region 1 (CR1) of this promoter to maintain a nucleosome-free region for gene activity. Retinoic acid (RA) rapidly down-regulates Pml, resulting in the replacement of BRGC with ...
31 CitationsSource
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