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Come avviare il paziente obeso alla terapia chetogenica

Published on Aug 1, 2019
· DOI :10.1007/s40619-019-00602-4
Eleonora Moriconi (Policlinico Umberto I), Marco Infante2
Estimated H-index: 2
+ 2 AuthorsMassimiliano Caprio25
Estimated H-index: 25
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Abstract
La very-low-calorie-ketogenic-diet (VLCKD) rappresenta un valido strumento nel trattamento dell’obesita e delle sue comorbidita. Il vantaggio di una VLCKD rispetto a un trattamento ipocalorico tradizionale e rappresentato dal rapido calo ponderale, dal mantenimento della massa muscolare e dalla riduzione dell’appetito. La VLCKD e spesso utilizzata all’interno di un percorso di educazione alimentare che abitua gradualmente il paziente a consumare porzioni di cibo piu piccole, ponendo maggiore attenzione ad alcune categorie di alimenti. La VLCKD, determinando un rapido calo ponderale, rende spesso possibile la riduzione, o addirittura la sospensione, delle terapie farmacologiche in corso nei pazienti complessi poli-trattati, con un importante miglioramento della qualita della vita.
  • References (22)
  • Citations (0)
References22
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#1Massimiliano Caprio (OU: Open University)H-Index: 25
#2Marco Infante (University of Rome Tor Vergata)H-Index: 2
Last. Andrea Lenzi (Sapienza University of Rome)H-Index: 57
view all 36 authors...
Background Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notab...
2 CitationsSource
#1Alice Albanese (UNIPD: University of Padua)H-Index: 5
#2Luca Prevedello (UNIPD: University of Padua)H-Index: 8
Last. Mirto Foletto (UNIPD: University of Padua)H-Index: 32
view all 6 authors...
Background Pre-operative diet may play an important role as far as patients’ fitness for surgery, post-operative outcomes, and successful weight loss. Our aim was to compare surgical outcome and weight loss in two groups of patients who were offered two different pre-operative kinds of diet: very low calorie diet (VLCD) and very low calorie ketogenic diet (VLCKD).
4 CitationsSource
#1Ana I. CastroH-Index: 7
Last. Felipe F. CasanuevaH-Index: 90
view all 10 authors...
Psychological well-being and hunger and food control are two relevant factors involved in the success of weight-loss therapy in treating obesity. Thus, this study aims to evaluate food and alcohol cravings, physical and sexual activity, sleep, and life quality (QoL) in obese patients following a very low-calorie ketogenic (VLCK) diet, as well as the role of weight lost and ketosis on these parameters. A battery of psychological test was performed in twenty obese patients (12 females, 47.2 ± 10.2...
7 CitationsSource
#1Alessandro PintoH-Index: 1
#2Alessio BonucciH-Index: 1
Last. Rita BusinaroH-Index: 17
view all 5 authors...
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease. The main activity of the ketogenic diet has been related to improved mitochondrial function and decreased oxidative stress. B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular e...
19 CitationsSource
#1Dhiren K. Patel (VA Boston Healthcare System)H-Index: 1
#2Fatima Cody Stanford (Harvard University)H-Index: 12
ABSTRACTThe prevalence of obesity and associated comorbidities is rising. Despite their weight-loss efficacy, new generation anti-obesity medications are only prescribed to a minority of adults with obesity, possibly, which in part may be due to safety concerns. This review presents detailed safety profiles for orlistat, phentermine/topiramate, lorcaserin, naltrexone/bupropion and liraglutide 3.0 mg, and discusses the associated risk–benefit profiles. Two anti-obesity medications presented safet...
14 CitationsSource
#2Ana B. CrujeirasH-Index: 29
Last. Felipe F. CasanuevaH-Index: 90
view all 10 authors...
Background The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet induced severe body weight (BW) loss.
5 CitationsSource
18 CitationsSource
#2Diego BellidoH-Index: 6
Last. Felipe F. Casanueva (ISCIII: Carlos III Health Institute)H-Index: 90
view all 10 authors...
Context: A common concern when using low-calorie diets as a treatment for obesity is the reduction in fat-free mass, mostly muscular mass that occurs together with the fat mass loss, and the best methodologies to evaluate body composition changes. Objective: To evaluate the very low-calorie-ketogenic (VLCK) diet-induced changes in body composition of obese patients and to compare three different methodologies employed to evaluate that changes. Design: Twenty obese patients followed a VLCK diet f...
24 CitationsSource
#1Albert Goday (Autonomous University of Barcelona)H-Index: 24
#2D. BellidoH-Index: 6
Last. Felipe F. Casanueva (Ciber)H-Index: 90
view all 9 authors...
Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus
32 CitationsSource
Obesity plays a relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional and metabolic factors. We conducted a dietary intervention case-control randomized trial, to compare the effectiveness on body composition of two nutritional protocols: a very-low-carbohydrate ketogenic diet (VLCKD), integrated by an aminoacid supplement with whey protein, and very low restricted-calorie diet (VLCD).The clinical study was conduc...
8 Citations
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