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Massimiliano Caprio
Open University
90Publications
25H-index
2,654Citations
Publications 92
Newest
#2Vincenzo MarzollaH-Index: 9
Last.Mahir KarakasH-Index: 22
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Cardiovascular diseases (CVDs) comprise 45% of all deaths in Europe and causes 3.9 million deaths annually. Coronary artery disease (CAD) which includes myocardial infarction (MI) represents the most common form of CVD. A relevant proportion of MI cases seems preventable since reports claim that up to two-thirds of these patients exhibit symptoms suggestive for MI within 12 months prior to the acute MI event. An early identification of these at-risk subjects is necessary to manage an early and e...
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#1Alessandra FeracoH-Index: 5
#2Vincenzo MarzollaH-Index: 9
Last.Massimiliano Caprio (OU: Open University)H-Index: 25
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Over the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR in the vasculature and in adipose tissue favors the occurrence of several components of the metabolic syndrome (MetS), such as hypertension, obesity, and glucose intolerance. Accordingly, high levels of aldosterone are associated with obesity and MetS in huma...
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RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentiation/activation and calcium release from the skeleton, different studies have elucidated its specific role in mammary gland physiology and hormone-driven epithelial proliferation du...
1 CitationsSource
#1Massimiliano Caprio (OU: Open University)H-Index: 25
#2Marco Infante (University of Rome Tor Vergata)H-Index: 2
Last.Andrea Lenzi (Sapienza University of Rome)H-Index: 57
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Background Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notab...
2 CitationsSource
#1Andrea ArmaniH-Index: 12
#2Vincenzo MarzollaH-Index: 9
Last.Massimiliano CaprioH-Index: 25
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#1Marco Infante (University of Rome Tor Vergata)H-Index: 1
#2Camillo RicordiH-Index: 83
Last.AndreaFabbri (University of Rome Tor Vergata)H-Index: 41
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Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses...
2 CitationsSource
#2Stefania GoriniH-Index: 8
Last.Massimiliano Caprio (OU: Open University)H-Index: 25
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The mineralocorticoid receptor (MR) was originally identified as a regulator of blood pressure, able to modulate renal sodium handling in response to its principal ligand aldosterone. MR is also expressed in many tissues other than kidney, including the heart, vasculature and adipose tissue. More recent studies have shown that extra-renal MR plays a relevant role in the control of cardiovascular and metabolic functions and has recently been implicated in the pathophysiology of aging. MR activati...
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#1Andrea M. ArmaniH-Index: 20
#2Marco Infante (UM: University of Miami)H-Index: 1
Last.Massimiliano Caprio (OU: Open University)H-Index: 25
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#1Eleonora Moriconi (Policlinico Umberto I)
#2Marco InfanteH-Index: 2
Last.Massimiliano CaprioH-Index: 25
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La very-low-calorie-ketogenic-diet (VLCKD) rappresenta un valido strumento nel trattamento dell’obesita e delle sue comorbidita. Il vantaggio di una VLCKD rispetto a un trattamento ipocalorico tradizionale e rappresentato dal rapido calo ponderale, dal mantenimento della massa muscolare e dalla riduzione dell’appetito. La VLCKD e spesso utilizzata all’interno di un percorso di educazione alimentare che abitua gradualmente il paziente a consumare porzioni di cibo piu piccole, ponendo maggiore att...
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#1M. Elizabeth Moss (Tufts University)H-Index: 4
#2Qing Lu (Tufts Medical Center)H-Index: 11
Last.Iris Z. Jaffe (Tufts University)H-Index: 26
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OBJECTIVE: MR (mineralocorticoid receptor) activation is associated with cardiovascular ischemia in humans. This study explores the role of the MR in atherosclerotic mice of both sexes and identifies a sex-specific role for endothelial cell (EC)-MR in vascular inflammation. Approach and Results: In the AAV-PCSK9 (adeno-associated virus-proprotein convertase subtilisin/kexin type 9) mouse atherosclerosis model, MR inhibition attenuated vascular inflammation in males but not females. Further studi...
4 CitationsSource
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