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Massimiliano Caprio
Open University
84Publications
25H-index
2,522Citations
Publications 84
Newest
RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentiation/activation and calcium release from the skeleton, different studies have elucidated its specific role in mammary gland physiology and hormone-driven epithelial proliferation du...
#1Massimiliano Caprio (OU: Open University)H-Index: 25
#2Marco Infante (University of Rome Tor Vergata)H-Index: 2
Last.Eleonora Poggiogalle (Sapienza University of Rome)H-Index: 14
view all 36 authors...
Background Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical practice for weight loss and management of obesity-related comorbidities. Despite evidence on the clinical benefits of VLCKDs is rapidly emerging, some concern still exists about their potential risks and their use in the long-term, due to paucity of clinical studies. Notab...
#1Marco InfanteH-Index: 2
#2Camillo RicordiH-Index: 81
Last.Rodolfo AlejandroH-Index: 47
view all 12 authors...
Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses...
#1Stefania GoriniH-Index: 8
#2Seung Kyum Kim (Tufts Medical Center)H-Index: 1
Last.M. Caprio (Università telematica San Raffaele)H-Index: 1
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The mineralocorticoid receptor (MR) was originally identified as a regulator of blood pressure, able to modulate renal sodium handling in response to its principal ligand aldosterone. MR is also expressed in many tissues other than kidney, including the heart, vasculature and adipose tissue. More recent studies have shown that extra-renal MR plays a relevant role in the control of cardiovascular and metabolic functions and has recently been implicated in the pathophysiology of aging. MR activati...
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