Targeting the Interaction Between Apolipoprotein E and Amyloid Precursor Protein: A Novel Alzheimer’s Disease Therapy

SEE CORRESPONDING ARTICLE ON PAGE 208 A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves CognitionBiological PsychiatryVol. 86Issue 3PreviewThe ɛ4 isoform of apolipoprotein E (apoE4) is a major genetic risk factor for the development of sporadic Alzheimer’s disease (AD), and its modification has been an intense focus...