Physical inactivity and knee osteoarthritis in guinea pigs

To investigate whether and how a sedentary lifestyle contributes to knee osteoarthritis (OA) incidence and severity.An experiment was conducted using Hartley guinea pigs, an established idiopathic knee OA model. To simulate a sedentary lifestyle, growing animals (n = 18) were housed for 22 weeks in small cages that restricted their mobility, while another group of animals (n = 17) received daily treadmill exercise to simulate moderate physical...