Review paper
Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH
Abstract
Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often attenuated during macrophage or animal infections, supporting that these pathways are essential for pathogenesis and represent important new targets for drug discovery. This review examines a confluence of findings supporting that Mtb has restricted metabolism at acidic...
Paper Details
Title
Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH
Published Date
Nov 1, 2019
Journal
Volume
27
Issue
11
Pages
942 - 953
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