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Trends in Microbiology
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#1Timothy J. Foster (Trinity College, Dublin)H-Index: 82
The microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) are a family of proteins that are defined by the presence of two adjacent IgG-like folded subdomains. These promote binding to ligands by mechanisms that involve major conformational changes exemplified by the binding to fibrinogen by the ‘dock-lock-latch' mechanism or to collagen by the ‘collagen hug'. Clumping factors A and B are two such MSCRAMMs that have several important roles in the pathogenesis of Staphyloc...
2 CitationsSource
Most bacteria use toxins to exclude competitors. As the synthesis and delivery of these molecules entail considerable costs for the producers, their expression is tightly regulated, often by molecular systems detecting physiological stresses or environment-specific cues. However, the ecological connection between such systems and competitive behaviors is not always clear. Here, we review the regulation of antibacterial toxins and propose a conceptual framework organizing the decision-making proc...
1 CitationsSource
#1Stephanie Fulaz (UCD: University College Dublin)H-Index: 3
#2Stefania Vitale (UCD: University College Dublin)H-Index: 1
Last.Eoin Casey (UCD: University College Dublin)H-Index: 20
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The negative consequences of biofilms are widely reported. A defining feature of biofilms is the extracellular matrix, a complex mixture of biomacromolecules, termed EPS, which contributes to reduced antimicrobial susceptibility. EPS targeting is a promising, but underexploited, approach to biofilm control allowing disruption of the matrix and thereby increasing the susceptibility to antimicrobials. Nanoparticles (NPs) can play a very important role as 'carriers' of EPS matrix disruptors, and se...
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Streptococcus pneumoniae causes bacterial meningitis with a high fatality rate globally. Patients who survive have a significant risk of lasting disabilities. Schmidt et al . have identified bacterial proteins that play a crucial role in pneumococcal meningitis: AliB, part of an oligopeptide transporter, and ComDE of the competence regulator.
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#1Jacob J. Baker (MSU: Michigan State University)H-Index: 4
#2Shelby J. Dechow (MSU: Michigan State University)H-Index: 1
Last.Robert B. Abramovitch (MSU: Michigan State University)H-Index: 20
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Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often attenuated during macrophage or animal infections, supporting that these pathways are essential for pathogenesis and represent important new targets for drug discovery. This review examines a confluence of findings supporting that Mtb has restricted metabolism at acidic pH that results in the slowing of bacterial growth a...
1 CitationsSource
#1Lauren K. Nicastro (TU: Temple University)H-Index: 2
#2Çagla Tükel (TU: Temple University)H-Index: 19
Molecular mimicry is a common mechanism used by many bacteria to evade immune responses. In recent years, it has become evident that bacteria also decorate the extracellular matrix (ECM) of their biofilms with molecules that resemble those of the host. These molecules include amyloids and other proteins, polysaccharides, and extracellular DNA. Bacterial amyloids, like curli, and extracellular DNA are found in the biofilms of many species. Recent work demonstrated that curli and DNA form unique m...
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#1Katelyn C. Cook (Princeton University)H-Index: 2
#2Jorge A. Moreno (Princeton University)
Last.Ileana M. Cristea (Princeton University)H-Index: 41
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Peroxisomes are multifunctional organelles with roles in cellular metabolism, cytotoxicity, and signaling. The plastic nature of these organelles allows them to respond to diverse biological processes, such as virus infections, by remodeling their biogenesis, morphology, and composition to enhance specific functions. During virus infections in humans, peroxisomes act as important immune signaling organelles, aiding the host by orchestrating antiviral signaling. However, more recently it was disc...
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#1Tanita Wein (CAU: University of Kiel)H-Index: 4
#2Devani Romero Picazo (CAU: University of Kiel)H-Index: 1
Last.Tal Dagan (CAU: University of Kiel)H-Index: 29
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Symbiotic interactions between eukaryotes and prokaryotes are widespread in nature. Here we offer a conceptual framework to study the evolutionary origins and ecological circumstances of species in beneficial symbiosis. We posit that mutual symbiotic interactions are well described by three elements: a currency, the mechanism of currency exchange, and mechanisms of symbiont inheritance. Each of these elements may be at the origin of symbiosis, with the other elements developing with time. The id...
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#1Margarida C. Gomes (Lond: University of London)H-Index: 1
#2Serge Mostowy (Lond: University of London)H-Index: 35
Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions in vivo because of their optical transparency, genetic manipulability, and translational potential. The development of the zebrafish immune system is well understood, thereby use of larvae enables investigation solely in the context of innate immunity. As a result, infection of zebrafish with natural fish pathogens including Mycobacterium marinum has significantly advanced our understanding of bacterial ...
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#1Alan Sulpizio (Cornell University)H-Index: 2
#2Marena E. Minelli (Cornell University)H-Index: 1
Last.Yuxin Mao (Cornell University)H-Index: 22
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Legionella pneumophila encodes a family of phosphoribosyl ubiquitination ligases (SidE) essential for the bacterium to establish successful infection. Four independent studies now show that the SidE family of ubiquitin ligases are regulated by a novel mechanism of glutamylation via a pseudokinase-like Legionella effector, SidJ, in an ATP- and calmodulin-dependent manner.
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