Review paper
Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study
Abstract
Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition of IL18 has been shown to reverse this enterocolitis, we undertook a Mendelian randomization study to test the causal effect of...
Paper Details
Title
Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study
Published Date
Jun 28, 2019
Journal
Volume
9
Issue
1
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