J. Brent Richards
McGill University
Publications 158
#1Yongjie Yang (BCM: Baylor College of Medicine)H-Index: 8
#2Agatha A. van der Klaauw (University of Cambridge)H-Index: 15
Last.Antentor Othrell Hinton (BCM: Baylor College of Medicine)H-Index: 8
view all 26 authors...
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozy...
#1Lauren E. Mokry (McGill University)H-Index: 7
#2Sirui Zhou (McGill University)H-Index: 7
Last.Philippe Sanseau (GSK: GlaxoSmithKline)H-Index: 21
view all 12 authors...
Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition of IL18 has been shown to reverse this enterocolitis, we undertook a Mendelian randomization study to test the causal effect of elevated IL18 levels on inflammatory bowel disease s...
#1Agustin Cerani (McGill University)H-Index: 1
#2Sirui Zhou (McGill University)H-Index: 7
Last.J. Brent Richards (McGill University)H-Index: 44
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Abstract Objective To determine if genetically increased serum calcium levels are associated with improved bone mineral density and a reduction in osteoporotic fractures. Design Mendelian randomisation study. Setting Cohorts used included: the UK Biobank cohort, providing genotypic and estimated bone mineral density data; 25 cohorts from UK, USA, Europe, and China, providing genotypic and fracture data; and 17 cohorts from Europe, providing genotypic and serum calcium data (summary level statist...
#1George Davey-Smith (UoB: University of Bristol)H-Index: 177
#2Neil M Davies (UoB: University of Bristol)H-Index: 20
Last.J. Brent Richards (McGill University)H-Index: 44
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#1Yi-Hsin Hsu (Harvard University)H-Index: 32
#2Karol EstradaH-Index: 41
Last.Jane A. CauleyH-Index: 146
view all 52 authors...
Hip geometry is an important predictor of fracture. We performed a meta-analysis of GWAS studies in adults to identify genetic variants that are associated with proximal femur geometry phenotypes. We analyzed four phenotypes: (i) femoral neck length; (ii) neck-shaft angle; (iii) femoral neck width, and (iv) femoral neck section modulus, estimated from DXA scans using algorithms of hip structure analysis. In the Discovery stage, 10 cohort studies were included in the fixed-effect meta-analysis, w...
#1John A. Morris (McGill University)H-Index: 10
#2John P. Kemp (UoB: University of Bristol)H-Index: 41
Last.Aaron KleinmanH-Index: 8
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In the version of this article initially published, in Fig. 5a, the data in the right column of ‘DAAM2 gRNA1’ were incorrectly plotted as circles indicating ‘untreated’ rather than as squares indicating ‘treated’. The error has been corrected in the HTML and PDF versions of the article.
#1Adil Harroud (McGill University)H-Index: 3
#2Adil Harroud (McGill University)H-Index: 1
Last.J. Brent RichardsH-Index: 44
view all 7 authors...
Objective To investigate the potential for a causal effect of age at puberty on multiple sclerosis (MS) susceptibility using a mendelian randomization (MR) approach. Methods We used 372 genetic variants strongly associated with age at menarche in a genome-wide association study (GWAS) involving 329,245 women. The genetic architecture of pubertal timing across both sexes is highly correlated (genetic correlation [ r g ] = 0.75, p = 1.2 × 10 −79 ), allowing these variants to provide reliable insig...