Efficient base editing for multiple genes and loci in pigs using base editors
Abstract
Cytosine base editors (CBEs) enable programmable C-to-T conversion without DNA double-stranded breaks and homology-directed repair in a variety of organisms, which exhibit great potential for agricultural and biomedical applications. However, all reported cases only involved C-to-T substitution at a single targeted genomic site. Whether C-to-T substitution is effective in multiple sites/loci has not been verified in large animals. Here, by using...
Paper Details
Title
Efficient base editing for multiple genes and loci in pigs using base editors
Published Date
Jun 28, 2019
Journal
Volume
10
Issue
1
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