No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
Abstract
CRISPR-Cas9 technologies have transformed genome-editing of experimental organisms and have immense therapeutic potential. Despite significant advances in our understanding of the CRISPR-Cas9 system, concerns remain over the potential for off-target effects. Recent studies have addressed these concerns using whole-genome sequencing (WGS) of gene-edited embryos or animals to search for de novo mutations (DNMs), which may represent candidate...
Paper Details
Title
No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
Published Date
Jul 9, 2018
Journal
Volume
14
Issue
7
Pages
e1007503 - e1007503
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