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#1María Angélica Bravo Núñez (Stowers Institute for Medical Research)H-Index: 3
#2Ibrahim M. Sabbarini (Stowers Institute for Medical Research)
Last.Sarah E. Zanders (Stowers Institute for Medical Research)H-Index: 6
view all 7 authors...
Meiotic drivers are selfish alleles that can force their transmission into more than 50% of the viable gametes made by heterozygotes. Meiotic drivers are known to cause infertility in a diverse range of eukaryotes and are predicted to affect the evolution of genome structure and meiosis. The wtf gene family of Schizosaccharomyces pombe includes both meiotic drivers and drive suppressors and thus offers a tractable model organism to study drive systems. Currently, only a handful of wtf genes have...
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#1Feng Zhang (SDU: Shandong University)H-Index: 4
#2Wenqing Tao (SDU: Shandong University)
Last.Zhaojun Ding (SDU: Shandong University)H-Index: 23
view all 8 authors...
The development of lateral roots in Arabidopsis thaliana is strongly dependent on signaling directed by the AUXIN RESPONSE FACTOR7 (ARF7), which in turn activates LATERAL ORGAN BOUNDARIES DOMAIN (LBD) transcription factors (LBD16, LBD18 and LBD29). Here, the product of PRH1, a PR-1 homolog annotated previously as encoding a pathogen-responsive protein, was identified as a target of ARF7-mediated auxin signaling and also as participating in the development of lateral roots. PRH1 was shown to be s...
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#1Wei-Chun Au (NIH: National Institutes of Health)H-Index: 7
#2Tianyi Zhang (NIH: National Institutes of Health)
Last.Anastasia BaryshnikovaH-Index: 27
view all 18 authors...
Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cells. Overexpression and mislocalization of CENP-A has been observed in many cancers and this correlates with increased invasiveness and poor prognosis. Yet genes that regulate CENP-A levels and localization under physiological conditions have not been ...
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#1Esther A. Epum (Vandy: Vanderbilt University)H-Index: 2
#2Michael J. Mohan (Vandy: Vanderbilt University)
Last.Katherine L. Friedman (Vandy: Vanderbilt University)H-Index: 14
view all 4 authors...
DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions. We previously identified sequences in Saccharomyces cerevisiae (SiRTAs; Sites of Repair-associated Telomere Addition) that undergo unusually high frequencies of de novo telomere addition, even when the original chromosome break is several kilobases ...
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#1Hu Fang (Li Ka Shing Faculty of Medicine, University of Hong Kong)
#2Jayne A. Barbour (UNSW: University of New South Wales)H-Index: 1
Last.Jason W. H. Wong (UNSW: University of New South Wales)H-Index: 28
view all 6 authors...
Cancer genomes with mutations in the exonuclease domain of Polymerase Epsilon (POLE) present with an extraordinarily high somatic mutation burden. In vitro studies have shown that distinct POLE mutants exhibit different polymerase activity. Yet, genome-wide mutation patterns and driver mutation formation arising from different POLE mutants remains unclear. Here, we curated somatic mutation calls from 7,345 colorectal cancer samples from published studies and publicly available databases. These i...
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#1Satesh Ramdhani (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Elisa Navarro (ISMMS: Icahn School of Medicine at Mount Sinai)
Last.Towfique Raj (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 30
view all 8 authors...
Recent human genetic studies suggest that cells of the innate immune system have a primary role in the pathogenesis of neurodegenerative diseases. However, the results from these studies often do not elucidate how the genetic variants affect the biology of these cells to modulate disease risk. Here, we applied a tensor decomposition method to uncover disease associated gene networks linked to distal genetic variation in stimulated human monocytes and macrophages gene expression profiles. We repo...
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#1Yuichi Shichino (National Institute for Basic Biology, Japan)H-Index: 6
#2Yoko Otsubo (National Institute for Basic Biology, Japan)H-Index: 8
Last.Akira Yamashita (National Institute for Basic Biology, Japan)H-Index: 23
view all 4 authors...
Accurate target recognition in transcript degradation is crucial for regulation of gene expression. In the fission yeast Schizosaccharomyces pombe, a number of meiotic transcripts are recognized by a YTH-family RNA-binding protein, Mmi1, and selectively degraded by the nuclear exosome during mitotic growth. Mmi1 forms nuclear foci in mitotically growing cells, and the nuclear exosome colocalizes to such foci. However, it remains elusive how Mmi1 and the nuclear exosome are connected. Here, we sh...
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#1Lianfeng Lin (HKU: University of Hong Kong)H-Index: 1
#2Quanwei Lyu (HKU: University of Hong Kong)H-Index: 1
Last.Kwok On Lai (HKU: University of Hong Kong)H-Index: 19
view all 10 authors...
Perturbation of synapse development underlies many inherited neurodevelopmental disorders including intellectual disability (ID). Diverse mutations on the human TBC1D24 gene are strongly associated with epilepsy and ID. However, the physiological function of TBC1D24 in the brain is not well understood, and there is a lack of genetic mouse model that mimics TBC1D24 loss-of-function for the study of animal behaviors. Here we report that TBC1D24 is present at the postsynaptic sites of excitatory sy...
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#1Christopher A. Jenkins (Animal Health Trust)H-Index: 4
#2Lajos Kalmár (University of Cambridge)H-Index: 18
Last.Sally L. Ricketts (Animal Health Trust)H-Index: 3
view all 10 authors...
A form of hereditary cerebellar ataxia has recently been described in the Norwegian Buhund dog breed. This study aimed to identify the genetic cause of the disease. Whole-genome sequencing of two Norwegian Buhund siblings diagnosed with progressive cerebellar ataxia was carried out, and sequences compared with 405 whole genome sequences of dogs of other breeds to filter benign common variants. Nine variants predicted to be deleterious segregated among the genomes in concordance with an autosomal...
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#1Andrew C. Read (Cornell University)H-Index: 2
#2Matthew J. Moscou (UEA: University of East Anglia)H-Index: 18
Last.Adam J. Bogdanove (Cornell University)H-Index: 37
view all 10 authors...
Long-read sequencing facilitates assembly of complex genomic regions. In plants, loci containing nucleotide-binding, leucine-rich repeat (NLR) disease resistance genes are an important example of such regions. NLR genes constitute one of the largest gene families in plants and are often clustered, evolving via duplication, contraction, and transposition. We recently mapped the Xo1 locus for resistance to bacterial blight and bacterial leaf streak, found in the American heirloom rice variety Caro...
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