Original paper
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Abstract
Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. We comprehensively show that loss of methylation in PMDs occurs in a large fraction of...
Paper Details
Title
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Published Date
Apr 15, 2019
Journal
Volume
10
Issue
1
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Notes
History