Hendrik G. Stunnenberg
Radboud University Nijmegen
Molecular biologyEpigeneticsGeneticsChromatinBiology
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Publications 382
#1Emma Bell (Imperial College London)H-Index: 3
#2Edward Curry (Imperial College London)H-Index: 10
Last. Hendrik Marks (Radboud University Nijmegen)H-Index: 23
view all 13 authors...
Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the existence of two types of enhancer units within SEs typified by distinctive CpG methylation dynamics in embryonic stem cells (ESCs). We find that these units are either prone for decommissioning or remain constitutively active in epiblast stem cells (...
#1Elja M.M. LouerH-Index: 1
#2Dorothee GünzelH-Index: 34
Last. Peter M. T. DeenH-Index: 44
view all 8 authors...
Abstract Strong communication and interaction between the retinal pigment epithelium (RPE) and the photoreceptor (PR) cells is essential for vision. RPE cells are essential for supporting and maintaining PR cells by transporting nutrients, waste products and ions, and phagocytosing photoreceptor outer segments (POS). POS phagocytosis follows a circadian pattern, taking place in the morning in human, mice and other organisms. However, it remains unknown whether other RPE processes follow a daily ...
#1Rosaria BenedettiH-Index: 13
#2Francesco Bajardi (INFN: Istituto Nazionale di Fisica Nucleare)H-Index: 1
Last. M. Valadan (INFN: Istituto Nazionale di Fisica Nucleare)
view all 10 authors...
AbstractA novel technique was demonstrated that overcomes important drawbacks to crosslink cells by irradiation with ultrashort ultraviolet laser pulses (L-crosslinking). To use this technique coup...
#1Rosaria BenedettiH-Index: 13
#2Francesco BajardiH-Index: 1
Last. Mohammadhassan ValadanH-Index: 3
view all 12 authors...
A novel technique was demonstrated that overcome important drawbacks to crosslink cells by irradiation with ultrashort UV laser pulses (L-crosslinking). To use this technique coupled to Chromatin ImmunoPrecipitation (ChIP) in a high throughput context, a pre-screening fast method needs to be implemented to set up suitable irradiation conditions of the cell sample for efficient L-crosslinking with no final and long ChIP analysis. Here a fast method is reported where living human cells have been f...
#1Pavlo G. Gritsenko (Radboud University Nijmegen)H-Index: 5
#2Nader Atlasy (Radboud University Nijmegen)
Last. Peter Friedl (Radboud University Nijmegen)H-Index: 62
view all 14 authors...
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium transients and mediate directional persistence. Downregulati...
#1René A. M. Dirks (Radboud University Nijmegen)H-Index: 5
#2Peter C. Thomas (Fluidigm Corporation)H-Index: 1
Last. Hendrik Marks (Radboud University Nijmegen)H-Index: 23
view all 5 authors...
Epigenetic profiling by ChIP-Seq has become a powerful tool for genome-wide identification of regulatory elements, for defining transcriptional regulatory networks and for screening for biomarkers. However, the ChIP-Seq protocol for low-input samples is laborious, time-consuming and suffers from experimental variation, resulting in poor reproducibility and low throughput. Although prototypic microfluidic ChIP-Seq platforms have been developed, these are poorly transferable as they require sophis...
#1Rosaria BenedettiH-Index: 13
Last. Lucia AltucciH-Index: 49
view all 22 authors...
In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-localize with estrogen receptors (ERs), suggesting the potential use of hybrid (epi)molecules to target histone methylation and therefore regulate/redirect hormone receptor signaling. Here, we report on the biological activity of a dual-KDM inhibitor (MC3324)...
#1Wieteke A. M. Hoeijmakers (Radboud University Nijmegen)H-Index: 11
#2Jun Miao (USF: University of South Florida)H-Index: 20
Last. Richárd Bártfai (Radboud University Nijmegen)H-Index: 18
view all 14 authors...
#1Elisa JenthoH-Index: 1
#2Boris Novakovic (University of Melbourne)H-Index: 23
Last. Sebastian WeisH-Index: 7
view all 20 authors...
Trained immunity defines long-lasting adaptive responses of innate immunity, mediated by transcriptional and epigenetic modifications of myeloid cells. Here, we report that labile heme, an alarmin released extracellularily upon tissue damage and hemolysis, induces trained immunity in human and murine primary cells and in mice. Heme-trainning in monocytes is associated with epigenetic and transcriptional profiles that overlap to some extent with those seen in beta-glucan-training, the prototype a...
#2Roser Vilarrasa-Blasi (University of Barcelona)H-Index: 5
Last. Marc A. Martí RenomH-Index: 37
view all 19 authors...
Despite recent advances, the dynamics of genome architecture and chromatin function during human cell differentiation and its potential reorganization upon neoplastic transformation remains poorly characterized. Here, we integrate in situ Hi-C and nine additional omic layers to define and biologically characterize the dynamic changes in three-dimensional (3D) genome architecture across normal B cell differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia (...
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