Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis

•Antigen-specific CD8+ T cells can control bile acid metabolism in a murine model of cholangitis. •The effect of T cells on bile acid metabolism partly depends on TNF and IFN-γ, and on T cell contact with hepatocytes. •Understanding the effect of lymphocytes on bile acid metabolism may help in the design of combined treatment strategies. Background & Aims T cells are central mediators of liver inflammation and represent potential treatment...