Original paper
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice
Abstract
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes, including endurance exercise performance in athletes. However, the phenotypic consequences of limited levels of naturally arising heteroplasmy have not been experimentally studied to date. We hence generated a conplastic mouse strain...
Paper Details
Title
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice
Published Date
Apr 12, 2018
Journal
Volume
8
Issue
1
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Notes
History