Review paper
The druggable genome and support for target identification and validation in drug development
Abstract
Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease biomarkers and disease end points) are important steps in drug development. Clinically relevant associations of variants in genes encoding drug targets model the effect of modifying the same targets pharmacologically. To delineate drug development (including repurposing) opportunities arising...
Paper Details
Title
The druggable genome and support for target identification and validation in drug development
Published Date
Mar 29, 2017
Volume
9
Issue
383
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