The fragility of statistically significant results from clinical nutrition randomized controlled trials

Background & aims Recently, a parameter called “Fragility index” (FI) has been proposed, which measures how many events the statistical significance relies on. The lower the FI the more “fragile” the results, and thus more care should be taken when interpreting the results. Our aim in this study was to check FI of nutritional trials. Methods We conducted a systematic review of human clinical nutrition RCTs that report statistically significant...