The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets
Abstract
In mice, memory B (Bmem) cells can be divided into two subpopulations: CD80hi Bmem cells, which preferentially differentiate into plasma cells; and CD80lo Bmem cells, which become germinal center (GC) B cells during a recall response. We demonstrate that these distinct responses can be B-cell-intrinsic and essentially independent of B-cell receptor (BCR) isotypes. Furthermore, we find that the development of CD80hi Bmem cells in the primary...
Paper Details
Title
The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets
Published Date
Jun 21, 2019
Journal
Volume
8
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