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eLife
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#1Gary S. McDowellH-Index: 12
#2John KnutsenH-Index: 3
Last.Rebeccah S. LijekH-Index: 7
view all 5 authors...
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#1Jorge Torres-Paz (CNRS: Centre national de la recherche scientifique)H-Index: 1
#2Julien Leclercq (CNRS: Centre national de la recherche scientifique)H-Index: 1
Last.Sylvie Rétaux (CNRS: Centre national de la recherche scientifique)H-Index: 34
view all 3 authors...
Sequential developmental events, starting from the moment of fertilization, are crucial for the acquisition of animal body plan. Subtle modifications in such early events are likely to have a major impact in later morphogenesis, bringing along morphological diversification. Here, comparing the blind cave and the surface morphotypes of Astyanax mexicanus fish, we found heterochronies during gastrulation, producing organizer and axial mesoderm tissues with different properties, including differenc...
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#1Catherine A Eichel (UW: University of Wisconsin-Madison)H-Index: 1
#2Erick B Rios-Pérez (UW: University of Wisconsin-Madison)
Last.Gail A. Robertson (UW: University of Wisconsin-Madison)H-Index: 26
view all 7 authors...
Catastrophic arrhythmias and sudden cardiac death can occur with even a small imbalance between inward sodium currents and outward potassium currents, but mechanisms establishing this critical balance are not understood. Here, we show that mRNA transcripts encoding INa and IKr channels (SCN5A and hERG, respectively) are associated in defined complexes during protein translation. Using biochemical, electrophysiological and single molecule fluorescence localization approaches, we find that roughly...
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#1Marco Tjioe (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
#2Saurabh Shukla (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last.Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
view all 8 authors...
How cargoes move within a crowded cell, over long distances and at speeds nearly the same as when moving on unimpeded pathway, has long been mysterious. Through an in vitro forcegliding assay, which involves measuring nanometer displacement and piconewtons of force, we show that kinesins (from 2 to 8) communicate in a team by inducing tension (up to 4 pN) on the cargo. Kinesins adopt two distinct states, with one-third slowing down the microtubule and twothirds speeding it up. Resisting kinesins...
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#1Kerryn Berndsen (Dund.: University of Dundee)
#2Pawel Lis (Dund.: University of Dundee)H-Index: 11
Last.Dario R. Alessi (Dund.: University of Dundee)H-Index: 116
view all 12 authors...
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#1Tushar D. Bhagat (Albert Einstein College of Medicine)H-Index: 22
#2Dagny Von Ahrens (Albert Einstein College of Medicine)H-Index: 3
Last.Amit Verma (Albert Einstein College of Medicine)H-Index: 48
view all 32 authors...
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#1Nicholas C Vierra (UC Davis: University of California, Davis)
#2Michael Kirmiz (UC Davis: University of California, Davis)H-Index: 3
Last.James S. Trimmer (UC Davis: University of California, Davis)H-Index: 68
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#1Elliot Imler (UA: University of Arizona)H-Index: 1
#2Jin Sang Pyon (UA: University of Arizona)
Last.Konrad E. Zinsmaier (UA: University of Arizona)H-Index: 21
view all 7 authors...
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#1Wenyuan Li (PKU: Peking University)H-Index: 1
#2Yage Zhang (PKU: Peking University)
Last.Bo Zhang (PKU: Peking University)H-Index: 32
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#1Aaron M. Kerlin (HHMI: Howard Hughes Medical Institute)H-Index: 10
#2Mohar Boaz (HHMI: Howard Hughes Medical Institute)
Last.Karel Svoboda (HHMI: Howard Hughes Medical Institute)H-Index: 97
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