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eLife
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7.55
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6949
Papers 7227
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Published on 2019in eLife7.55
Di Fan , Zoubida Chettouh6
Estimated H-index: 6
+ 1 AuthorsJean-François Brunet40
Estimated H-index: 40
Published on 2019in eLife7.55
Jacob M. Graving2
Estimated H-index: 2
(MPG: Max Planck Society),
Daniel Chae (Princeton University)+ 4 AuthorsIain D. Couzin48
Estimated H-index: 48
(MPG: Max Planck Society)
Quantitative behavioral measurements are important for answering questions across scientific disciplines---from neuroscience to ecology. State-of-the-art deep-learning methods offer major advances in data quality and detail by allowing researchers to automatically estimate locations of an animal9s body parts directly from images or videos. However, currently-available animal pose estimation methods have limitations in speed and robustness. Here we introduce a new easy-to-use software toolkit, De...
Published on 2019in eLife7.55
Karen Baker2
Estimated H-index: 2
,
Irene Gyamfi1
Estimated H-index: 1
+ 3 AuthorsDaniel P. Mulvihill19
Estimated H-index: 19
Published on 2019in eLife7.55
Alexander D. Fulford1
Estimated H-index: 1
,
Maxine Holder7
Estimated H-index: 7
+ 3 AuthorsPaulo Souto Ribeiro22
Estimated H-index: 22
Published on Jun 28, 2019in bioRxiv
Hyung-Seok Kim (UofU: University of Utah), Judith M. Neugebauer3
Estimated H-index: 3
(UofU: University of Utah)
+ 2 AuthorsL. Christian31
Estimated H-index: 31
(UofU: University of Utah)
BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice carrying a mutation (Bmp7R-GFlag) that prevents proteolytic activation of the dimerized BMP7 precursor protein. This mutation eliminates the function of BMP7 homodimers and all other BMPs that normally heterodimerize with BMP7. While Bmp7 null homozygotes are live born, Bmp7R-GFlag homozygotes are embryonic lethal an...
Published on 2019in bioRxiv
Benjamin G. Horst1
Estimated H-index: 1
(University of California, Berkeley),
Adam L Yokom (University of California, Berkeley)+ 4 AuthorsMichael A. Marletta58
Estimated H-index: 58
(University of California, Berkeley)
Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-specific stimulator YC-1 induce a 71° rotation of the heme-binding β H-NOX and PAS domains. Repositioning of the β H-NOX domain leads to a straightening of the coiled-coil domains, which, in turn, use the motion to move the catalytic domains int...
Published on 2019in eLife7.55
Dandan Han1
Estimated H-index: 1
,
Lars Schomacher3
Estimated H-index: 3
+ 6 AuthorsChristof Niehrs69
Estimated H-index: 69
The face of animals with a backbone is formed in great part by a group of cells called cranial neural crest cells. When too few of these cells are made, the skull and the face can become deformed. For example, the jaw- or cheekbones can be underdeveloped or there may be defects in the eyes or ears. These types of abnormalities are among the most common birth defects known in humans. NEIL1 and NEIL2 are mouse proteins with two roles. On the one hand, they help protect DNA from damage by acting as...
Published on Jan 16, 2019in bioRxiv
R.A. Pumroy2
Estimated H-index: 2
(UPenn: University of Pennsylvania),
Amrita Samanta (UPenn: University of Pennsylvania)+ 8 AuthorsTibor Rohacs30
Estimated H-index: 30
(RU: Rutgers University)
Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non-psychotropic therapeutically active ingredient of Cannabis sativa, is a potent activator of TRPV2 and also modulates other transient receptor potential (TRP) channels. Here, we determined structures of the full-length TRPV2 channel in a CBD-bound state in detergent and in PI(4,5)P 2 enriched nanodiscs by cryo-electron microscopy. CBD i...
Published on 2019in eLife7.55
Nina Y. Yao15
Estimated H-index: 15
(Rockefeller University),
Mike O'Donnell72
Estimated H-index: 72
(HHMI: Howard Hughes Medical Institute)
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