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Daisuke Kitamura
Tokyo University of Science
Molecular biologyImmunologyB cellSignal transductionBiology
136Publications
40H-index
8,295Citations
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Publications 130
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#1Tadahiro Kodama (Ridai: Tokyo University of Science)H-Index: 1
#2Mika Hasegawa (Ridai: Tokyo University of Science)
Last. Daisuke Kitamura (Ridai: Tokyo University of Science)H-Index: 40
view all 5 authors...
Upon antigen stimulation, IgG+ B cells rapidly proliferate and differentiate into plasma cells, which has been attributed to the characteristics of membrane-bound IgG (mIgG), but the underlying molecular mechanisms remain elusive. We have found that a part of mouse mIgG1 is ubiquitinated through the two responsible lysine residues (K378 and K386) in its cytoplasmic tail and this ubiquitination is augmented upon antigen stimulation. The ubiquitination of mIgG1 involves its immunoglobulin tail tyr...
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#1Takuya Nojima (Duke University)H-Index: 10
#2Alexander E. Reynolds (Duke University)H-Index: 3
Last. Masayuki Kuraoka (Duke University)H-Index: 13
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: BCR transgenic mice dominate studies of B cell tolerance; consequently, tolerance in normal mice expressing diverse sets of autoreactive B cells is poorly characterized. We have used single B cell cultures to trace self-reactivity in BCR repertoires across the first and second tolerance checkpoints and in tolerized B cell compartments of normal mice. This approach reveals affinity "setpoints" that define each checkpoint and a subset of tolerized, autoreactive B cells that is long-lived. In nor...
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#1Joel Finney (Duke University)H-Index: 3
#2Guang Yang (Duke University)H-Index: 8
Last. Garnett Kelsoe (Duke University)H-Index: 66
view all 9 authors...
2F5 is an HIV-1 broadly neutralizing Ab that also binds the autoantigens kynureninase (KYNU) and anionic lipids. Generation of 2F5-like Abs is proscribed by immune tolerance, but it is unclear which autospecificity is responsible. We sampled the BCR repertoire of 2F5 knock-in mice before and after the first and second tolerance checkpoints. Nearly all small pre-B (precheckpoint) and 35-70% of anergic peripheral B cells (postcheckpoint) expressed the 2F5 BCR and maintained KYNU, lipid, and HIV-1 ...
4 CitationsSource
#1Takuya Koike (Ridai: Tokyo University of Science)H-Index: 1
#2Koshi Harada (Ridai: Tokyo University of Science)H-Index: 1
Last. Daisuke Kitamura (Ridai: Tokyo University of Science)H-Index: 40
view all 4 authors...
: In mice, memory B (Bmem) cells can be divided into two subpopulations: CD80hi Bmem cells, which preferentially differentiate into plasma cells; and CD80lo Bmem cells, which become germinal center (GC) B cells during a recall response. We demonstrate that these distinct responses can be B-cell-intrinsic and essentially independent of B-cell receptor (BCR) isotypes. Furthermore, we find that the development of CD80hi Bmem cells in the primary immune response requires follicular helper T cells, a...
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#1Takuya Koike (Ridai: Tokyo University of Science)H-Index: 1
#2Koshi Harada (Ridai: Tokyo University of Science)H-Index: 1
Last. Daisuke Kitamura (Ridai: Tokyo University of Science)H-Index: 40
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#1Theresa Pesch (ETH Zurich)H-Index: 2
#2Lucia Bonati (ETH Zurich)H-Index: 1
Last. Sai T. Reddy (ETH Zurich)H-Index: 26
view all 8 authors...
Immune cell therapies based on the integration of synthetic antigen receptors provide a powerful strategy for the treatment of diverse diseases, most notably retargeting T cells engineered to express chimeric antigen receptors (CAR) for cancer therapy. In addition to T lymphocytes, B lymphocytes may also represent valuable immune cells that can be engineered for therapeutic purposes such as protein replacement therapy or recombinant antibody production. In this article, we report a promising con...
1 CitationsSource
#2Astrid ZahnH-Index: 7
Last. Javier M. Di NoiaH-Index: 28
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Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine protein modifications, is overexpressed in B cell lymphomas but its function in normal B cells is poorly defined. Here we show that Prmt5 is necessary for antibody responses and has essential but distinct functions in all proliferative B cell stages in m...
4 CitationsSource
#1Shogo TakatsukaH-Index: 3
#2Hiroyuki YamadaH-Index: 1
Last. Daisuke KitamuraH-Index: 40
view all 6 authors...
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#1Kei HaniudaH-Index: 5
#2Daisuke KitamuraH-Index: 40
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#1Paul Dascani (University of Louisville)H-Index: 2
#2Chuanlin Ding (University of Louisville)H-Index: 19
Last. Jun Yan (University of Louisville)H-Index: 43
view all 10 authors...
A mutation in STAT3 has been linked to the incidence of autosomal dominant hyper IgE syndrome, a disease characterized by elevated serum IgE Ab. However, how this genetic mutation leads to the phenotype has not been fully understood. We investigated the specific role of STAT3 in the germinal center (GC) B cells and plasma cells for IgE class switching. Through the use of STAT3 conditional knockout (cKO) mice in a Th2-type immunization model, we demonstrated that CD2-Cre–driven STAT3 cKO mice sho...
1 CitationsSource
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