Original paper
NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia
Abstract
Activating mutations in FMS-like tyrosine kinase receptor-3 (FLT3) and Nucleophosmin-1 (NPM1) are most frequent alterations in acute myeloid leukemia (AML), and are often coincidental. The mutational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 tyrosine kinase domain (TKD), but the biological mechanism underlying this effect remains unclear. In the present study, we investigated the effect of the...
Paper Details
Title
NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia
Published Date
Jul 25, 2019
Journal
Volume
134
Issue
4
Pages
383 - 388
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Notes
History