IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
Abstract
Clostridium difficile ( C. difficile ) incidence has tripled over the past 15 years and is attributed to the emergence of hypervirulent strains. While it is clear that C. difficile toxins cause damaging colonic inflammation, the immune mechanisms protecting from tissue damage require further investigation. Through a transcriptome analysis, we identify IL-33 as an immune target upregulated in response to hypervirulent C. difficile . We...
Paper Details
Title
IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection
Published Date
Jun 20, 2019
Journal
Volume
10
Issue
1
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