doi.org/10.1016/j.joca.2019.04.019
Original paper

Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis

..., Hong Zhou
40
Osteoarthritis and Cartilage7.20
Volume: 27, Issue: 10, Pages: 1518 - 1525
Published: Oct 1, 2019
Abstract
ObjectiveAging is a major risk factor for osteoarthritis (OA). Skeletal expression and activity of the glucocorticoid-activating enzyme 11β-hydroxysteroid-dehydrogenase type 1 increases progressively with age in humans and rodents. Here we investigated the role of endogenous osteocytic and osteoblastic glucocorticoid (GC) signalling in the development of osteoarthritic bone and cartilage damage in mice.MethodsWe utilized transgenic (tg) mice in...
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Paper Details
Title
Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis
DOI
doi.org/10.1016/j.joca.2019.04.019
Published Date
Oct 1, 2019
Journal
Osteoarthritis and Cartilage
Volume
27
Issue
10
Pages
1518 - 1525
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