1985-P: Inhibition of Adipocyte-Derived Serotonin Protects from High-Fat Diet-Induced Obesity by Increasing Energy Expenditure

Serotonin (5-HT) is a monoamine that has various functions in both neuronal and non-neuronal systems. 5-HT has been known as an anorexigenic neurotransmitter in central nervous system. However, accumulating evidences suggest that peripheral 5-HT may also affect organismal energy homeostasis. Here we demonstrate the role of adipocyte-derived 5-HT in the regulation of systemic energy metabolism. The expression of tryptophan hydroxylase-1 (Tph1),...