Caspase-11–Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis

Inflammasomes are multiprotein complexes that respond to infection or injury to activate inflammation. Inflammatory caspases, caspase-1, -4, and -5 in humans, and their murine orthologues caspase-1 and -11, are crucial components of inflammasomes, responsible for the maturation and secretion of IL-1β and IL-18 and for pyroptosis (inflammatory cell death) (Creagh, 2014Creagh E.M. Caspase crosstalk: integration of apoptotic and innate immune...