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Journal of Investigative Dermatology
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6.29
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27688
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#1Marvyn T. Koning (LUMC: Leiden University Medical Center)H-Index: 3
#2Edwin Quinten (LUMC: Leiden University Medical Center)H-Index: 12
Last.Maarten H. Vermeer (LUMC: Leiden University Medical Center)H-Index: 45
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Primary cutaneous follicle center lymphoma (PCFCL) is a rare mature B-cell lymphoma with an unknown etiology. PCFCL resembles follicular lymphoma (FL) by cytomorphologic and microarchitectural criteria. FL B cells are selected for N -linked glycosylation motifs in their B-cell receptors (BCRs) that are acquired during continuous somatic hypermutation. The stimulation of mannosylated BCR by lectins on the tumor microenvironment is therefore a candidate driver in FL pathogenesis. We investigated w...
#1Yi-Kai Hong (NCKU: National Cheng Kung University)
#2Yao-Chou Lee (NCKU: National Cheng Kung University)
Last.Chih-Yuan Ma (NCKU: National Cheng Kung University)H-Index: 1
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Tumor endothelial marker 1 (TEM1), also known as endosialin or CD248, is a type I transmembrane glycoprotein containing a C-type lectin-like domain. It is highly expressed in pericytes and fibroblasts. Dermal fibroblasts play a pivotal role during cutaneous wound healing, especially in the proliferative phase. However, the physiological function of TEM1 in wound healing is still undetermined. During the process of wound healing, the expression of both TEM1 and platelet-derived growth factor (PDG...
#1Jonathan I. Silverberg (NU: Northwestern University)H-Index: 36
#2Joel M. Gelfand (UPenn: University of Pennsylvania)H-Index: 53
Last.Eric L. Simpson (OHSU: Oregon Health & Science University)
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Quality-of-life assessments are not standardized in atopic dermatitis (AD). We sought to determine the validity of the Short Form (SF)-12, a generic quality-of-life assessment, in AD and compare its measurement properties with the Dermatology Life Quality Index (DLQI). A cross-sectional, population-based study of 3,495 adults was performed, including 602 adults who met the modified United Kingdom Working Party Criteria for AD. The SF-12 mental component score and the SF-Six Dimension (SF-6D) had...
#1Catherine Do (University of Texas at Austin)H-Index: 1
#2Viktor Drel (University of Texas at Austin)
Last.Brent Wagner (UNM: University of New Mexico)H-Index: 10
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Abstract Gadolinium-based contrast agents are implicated in several pathologic abnormalities (long-term retention in vital organs such as the skin and brain) and are the cause of a sometimes fatal condition in patients, ‘nephrogenic' systemic fibrosis (NSF). Bone marrow-derived fibrocytes and the monocyte chemoattractant protein 1 (MCP1) inflammatory pathway have been implicated as mediators of adverse effects induced by gadolinium-based contrast agents. Mechanistic studies are scant. A mouse mo...
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of celiac disease causing an itchy, blistering rash. Granular IgA deposits in the skin are pathognomonic for DH, and the treatment of choice is a lifelong gluten-free diet (GFD). Preliminary evidence suggests that there are patients with DH who redevelop gluten tolerance after adherence to a GFD treatment. To evaluate this, we performed a 12-month gluten challenge with skin and small-bowel mucosal biopsy samples in 19 patients wit...
#1Oliver Taylor (UTSW: University of Texas Southwestern Medical Center)
#2Rajiv I. Nijhawan (UTSW: University of Texas Southwestern Medical Center)H-Index: 10
#1Tingting Cui (Fourth Military Medical University)H-Index: 4
#2Weigang Zhang (Fourth Military Medical University)H-Index: 6
Last.J. Chen (Fourth Military Medical University)H-Index: 2
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Vitiligo is a cutaneous depigmentation disorder caused by the destruction of epidermal melanocytes. The generation and the skin infiltration of autoreactive CD8 + cytotoxic T cells triggered by oxidative stress play a critical role in vitiligo. High-mobility group protein B1 (HMGB1) is a classic damage-associated molecular pattern molecule with strong proinflammatory effects in inflammatory reactions. A previous study reported an enhanced expression of HMGB1 in vitiligo lesion, but the role of H...
#1K. Zakrzewska (UniFI: University of Florence)H-Index: 17
#2Rosaria Arvia (UniFI: University of Florence)H-Index: 7
Last.Clodoveo Ferri (University of Modena and Reggio Emilia)H-Index: 54
view all 9 authors...
Parvovirus B19 (B19V) has been proposed as a triggering agent for some autoimmune diseases including systemic sclerosis (SSc). In this study, we investigated whether B19V infection in vitro differently activates inflammatory pathways, including those dependent on caspase-1 activation, in monocytes from patients with SSc and healthy controls. We showed that B19V can infect both THP-1 cells and primary monocytes but is not able to replicate in these cells. B19V infection increases the production o...
#1Bing Li (Fourth Military Medical University)H-Index: 5
#2Jie Lei (Fourth Military Medical University)H-Index: 2
Last.Dalong Zhi (Fourth Military Medical University)
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Psoriasis is a T lymphocyte–driven systemic inflammatory disease. Regulatory T cells (Tregs) are essential for establishing and maintaining immune tolerance. In this study, we found that patients with psoriasis and healthy controls had comparable percentages of circulating CD4 + CD25 + FOXP3 + Tregs, but psoriatic Tregs had reduced suppressive function. Thereafter, mRNA arrays were performed to study the gene expression profile of psoriatic Tregs. Psoriatic Tregs expressed high levels of a T hel...
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