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Journal of Investigative Dermatology
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#1Qi ZhenH-Index: 1
#2Zhenjun YangH-Index: 2
Last.Liangdan SunH-Index: 28
view all 25 authors...
Genetic studies based on single-nucleotide polymorphisms have provided valuable insights into the genetic architecture of complex diseases. However, a large fraction of heritability for most of these diseases remains unexplained, and the impact of small insertions and deletions (InDels) has been neglected. We performed a comprehensive screen on the exome sequence data of 1,326 genes using the SOAP-PopIndel method for InDels in 32,043 Chinese Han individuals and identified 29 unreported InDels wi...
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#1Qingtai Su (Scott & White Hospital)H-Index: 1
#2Botond Z. Igyártó (Scott & White Hospital)H-Index: 1
The immune functions of epithelia-resident dendritic cells are influenced by epithelial-derived cytokines. Here we identified a communication form between tissue-resident dendritic cells and niche cells that allows direct intracellular material exchange between the parties. We show that many keratinocyte (KC)-specific molecules such as keratins and adhesion molecules could be detected in the epidermal-resident Langerhans cells (LCs) as mRNA and protein. Furthermore, KC-derived Cre led to genetic...
1 CitationsSource
#1Yo-Han Kim (Asan Medical Center)H-Index: 1
#2Donghwan Kim (Asan Medical Center)H-Index: 1
Last.Youngsup Song (Asan Medical Center)H-Index: 12
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Exposure to UVR stimulates the cAMP signaling pathway, which leads to melanin deposits in skin tissues. Although melanogenesis can be beneficial by protecting skin from UVR-induced damage, excessive or uneven deposits of melanin can cause various skin hyperpigmentation disorders. Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcriptio...
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#1Jacinto S. De La Cruz Diaz (University of Pittsburgh)H-Index: 2
#2Daniel H. Kaplan (University of Pittsburgh)H-Index: 32
Tunneling nanotubes (TNTs) have been described as a novel mechanism for intercellular communication. However, the ability of epidermal cells to utilize TNTs remains a mystery. In this issue, Su and Igyarto (2019) showed that Langerhans cells (LCs) obtain mRNA from keratinocytes (KC) in vivo presumably via TNTs. The demonstration of exchange of genetic material from KC to LC in vivo is an an unexpected method of antigen acquisition by LC and also an important consideration when analyzing transcri...
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#1Holly N. Wilkinson (Hull York Medical School)H-Index: 4
#2Sophie E. Upson (Hull York Medical School)H-Index: 1
Last.Matthew J. Hardman (Hull York Medical School)H-Index: 31
view all 6 authors...
Iron is crucial for maintaining normal bodily function with well-documented roles in erythropoiesis, hemostasis, and inflammation. Despite this, little is known about the temporal regulation of iron during wound healing, or how iron contributes to wound biology and pathology. In this study, we profiled tissue iron levels across a healing time-course, identifying iron accumulation during late-stage repair. Diabetic murine wounds displayed significantly reduced iron levels, delayed extracellular m...
1 CitationsSource
#1Sinead Kenealy (Trinity College, Dublin)H-Index: 1
#2Joan Manils (Trinity College, Dublin)H-Index: 1
Last.Emma M. Creagh (Trinity College, Dublin)H-Index: 19
view all 8 authors...
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#1Tanja Wagner (Medical University of Vienna)H-Index: 2
#2Lucian Beer (Medical University of Vienna)H-Index: 10
Last.Michael Mildner (Medical University of Vienna)H-Index: 33
view all 12 authors...
Cornifelin (CNFN) has been identified as a protein component of epidermal corneocytes. Here, we investigated the tissue distribution of CNFN and potential consequences of CNFN deficiency on epithelial function in in vitro models of human skin and oral mucosa. Our detailed bioinformatics and immunostaining analysis revealed that CNFN is not only expressed in human epidermis but also in noncornifying oral mucosa. In normal epidermis, CNFN was confined to the upper granular layer and the stratum co...
1 CitationsSource
#1Byung Eui KimH-Index: 16
#2Elena GolevaH-Index: 29
Last.Donald Y.M. LeungH-Index: 108
view all 7 authors...
Skin biopsies are commonly used for the assessment of skin pathology in various skin diseases, including atopic dermatitis (AD). However, because of the invasive nature of skin biopsies, many patients, particularly children, decline participation. This can lead to potential subject sampling bias as data could be skewed toward more severe, older patients who are willing to have biopsies. Recently, researchers have begun studying the skin with a minimal, noninvasive technique using skin tape strip...
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#1Attila Gábor Szöllősi (UCD: University College Dublin)
#2Ian McDonald (UCD: University College Dublin)H-Index: 3
Last.Martin SteinhoffH-Index: 66
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#1Océane Ducharme (University of Bordeaux)
#2Marie Beylot-Barry (University of Bordeaux)H-Index: 40
Last.Audrey Gros (University of Bordeaux)H-Index: 7
view all 12 authors...
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT) preferentially involves the lower limb in elderly subjects. A combination of polychemotherapy and rituximab has improved prognosis. However, about 50% of patients will experience progression or relapse without any predictive biologic marker of therapeutic response. The mutational profile of PCLBCL-LT has highlighted mutations contributing to constitutive NF-κB and B-cell receptor (BCR) signaling pathways but has not demonstrat...
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Top fields of study
Pathology
Immunology
Biochemistry
Biology
Epidermis (botany)