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Journal of Investigative Dermatology
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28659
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#1N. Talvard-Balland (French Institute of Health and Medical Research)
#2A. Sutra Del Galy (French Institute of Health and Medical Research)
Last. Nathalie ParquetH-Index: 8
view all 20 authors...
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#1Sarah Kam (BU: Boston University)
#2Marianne Collard (BU: Boston University)
Last. Rhoda M. Alani (BU: Boston University)H-Index: 28
view all 4 authors...
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#1Jemima E. Mellerio (Guy's and St Thomas' NHS Foundation Trust)H-Index: 35
#2Jouni Uitto (Thomas Jefferson University)H-Index: 97
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#1Emma Guttman-Yassky (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 49
#2Richard L. Gallo (UCSD: University of California, San Diego)H-Index: 100
Last. Maeda-Chubachi TH-Index: 1
view all 8 authors...
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#1Sajina Shakya (CSU: Cleveland State University)H-Index: 1
#2Judith A. Mack (Cleveland Clinic)H-Index: 12
Last. Edward V. Maytin (CSU: Cleveland State University)H-Index: 30
view all 4 authors...
Abstract We investigated how loss of tumor necrosis factor-stimulated gene-6 (TSG-6) affects wound closure and skin inflammation. TSG-6 has several known biological functions including enzymatic transfer of heavy chain proteins (HC) from inter-α-trypsin inhibitor to hyaluronan (HA) to form HC-HA complexes. TSG-6 and HC-HA are constitutively expressed in normal skin and increase post-wounding, but are completely absent in TSG-6 null mice. Wound closure rates are significantly delayed in TSG-6 nul...
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#1Yeongeun Kim (Ajou University)
#2Bogyeong Kang (Ajou University)
Last. Hee Young Kang (Ajou University)H-Index: 2
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Abstract Senescent fibroblasts play a role in aging pigmentation. In this study, we found that GDF15 expression levels are increased in UV-irradiated senescent fibroblasts and photoaged hyperpigmented skin. To investigate the effects of GDF15 on melanogenesis, normal human melanocytes were co-cultured with fibroblasts infected with the GDF15 lentivirus or sh-GDF15. It was found that GDF15 stimulates melanogenesis in melanocytes through MITF/tyrosinase upregulation via β-catenin signaling. The st...
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Abstract Fibroblasts produce collagens and other proteins that form the bulk of the extracellular matrix (ECM) in connective tissues. Emerging data point to functional heterogeneity of fibroblasts. However, the lack of sub-type specific markers hinders our understanding of the different roles of fibroblasts in ECM biology, wound healing, diseases and aging. We have investigated the utility of the cell surface protein CD26 (dipeptidyl peptidase-4) to identify functionally distinct fibroblast subp...
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#1Christine Youn (JHUSOM: Johns Hopkins University School of Medicine)
#2Nathan K. Archer (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
Last. Lloyd S. Miller (Janssen Pharmaceutica)
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Abstract Bacterial skin infections are a major societal health burden and are increasingly difficult to treat due to the emergence of antibiotic resistant strains such as community-acquired methicillin-resistant Staphylococcus aureus. Understanding the immunological mechanisms that provide durable protection against skin infections has the potential to guide the development of immunotherapies and vaccines to engage the host immune response to combat these antibiotic resistant strains. To this en...
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#1Gabriela Pinget (USYD: University of Sydney)H-Index: 2
#2J. Tan (USYD: University of Sydney)
Last. Laurence Macia (USYD: University of Sydney)H-Index: 25
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Abstract Psoriasis is a chronic inflammatory condition of the skin, autoimmune in nature, that affects millions of people worldwide. It is driven by IL-17-producing CD4 and γδ-T cells and targeted by current anti-IL-17 or anti-IL-23 monoclonal antibody therapies. These treatments are expensive, increase the risk of opportunistic infections and do not specifically target the inflammatory cascade. Other cells, including inflammatory monocytes have been shown to migrate to psoriatic plaques in both...
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#1Mai Q. NguyenH-Index: 1
#2Jessica L. F. TehH-Index: 7
Last. Andrew E. Aplin (Thomas Jefferson University)H-Index: 34
view all 10 authors...
ABSTRACT Melanomas frequently harbor activating NRAS mutations leading to activation of MEK-ERK1/2 signaling; however, clinical efficacy of inhibitors to this pathway are limited by resistance. Tumors re-wire metabolic pathways in response to stress signals such as targeted inhibitors and drug resistance, but most therapeutic resistant pre-clinical models are generated in conditions that lack physiological metabolism. We generated human NRAS mutant melanoma xenografts that were resistant to the ...
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Top fields of study
Pathology
Immunology
Biochemistry
Biology
Epidermis (botany)