HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1
Abstract
HIV-1 replication in CD4-positive T lymphocytes requires counteraction of multiple different innate antiviral mechanisms. Macrophage cells are also thought to provide a reservoir for HIV-1 replication but less is known in this cell type about virus restriction and counteraction mechanisms. Many studies have combined to demonstrate roles for APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H in HIV-1 restriction and mutation in CD4-positive T lymphocytes,...
Paper Details
Title
HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1
Published Date
Jul 1, 2019
Journal
Volume
100
Issue
7
Pages
1140 - 1152
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Notes
History