Journal of General Virology
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#1Jingfang Wang (CAS: Chinese Academy of Sciences)
#2Xintian Xu (CAS: Chinese Academy of Sciences)H-Index: 1
Last. HAOPei (CAS: Chinese Academy of Sciences)H-Index: 18
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We constructed complex models of SARS-CoV-2 spike protein binding to pangolin or human ACE2, the receptor for virus transmission, and estimated the binding free energy changes using molecular dynamics simulation. SARS-CoV-2 can bind to both pangolin and human ACE2, but has a significantly lower binding affinity for pangolin ACE2 due to the increased binding free energy (9.5 kcal mol−1). Human ACE2 is among the most polymorphous genes, for which we identified 317 missense single-nucleotide variat...
#1Jan Kreuze (CIP: International Potato Center)H-Index: 26
#2A. M. VairaH-Index: 18
Last. Ki Hyun Ryu (Seoul Women's University)H-Index: 19
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The family Alphaflexiviridae includes viruses with flexuous filamentous virions that are 470–800 nm in length and 12–13 nm in diameter. Alphaflexiviruses have a single-stranded, positive-sense RNA genome of 5.5–9 kb. They infect plants and plant-infecting fungi. They share a distinct lineage of alphavirus-like replication proteins that is unusual in lacking any recognized protease domain. With a single exception, cell-to-cell and long-distance movement is facilitated by triple gene block protein...
#1Tao Zhang (THU: Tsinghua University)H-Index: 4
#2Kai Fan (CAU: China Agricultural University)
Last. Ruiyun Li (Imperial College London)H-Index: 1
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The predominance of H5N6 in ducks and continuous human cases have heightened its potential threat to public health in China. Therefore, the detection of emerging variants of H5N6 avian influenza viruses has become a priority for pandemic preparedness. Questions remain as to its origin and circulation within the wild bird reservoir and interactions at the wild–domestic interface. Samples were collected from migratory birds in Poyang Lake, Jiangxi Province, PR China during the routine bird ring su...
#1Sarah François (University of Oxford)
#2Oliver G Pybus (RVC: Royal Veterinary College)
Last. Oliver G. Pybus (University of Oxford)H-Index: 77
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The last two decades have seen the rise of viromics, the study of viral communities through the detection and characterization of virus genome sequences. Here we systematically review and summarize the scope and limitations of our current understanding of avian viromes, in both domesticated and wild-bird populations. We compare this viromic work to the broader literature on avian prokaryotic microbiomes, and highlight the growing importance of structured sampling and experimental design for test...
#1Hana Elasifer (Cardiff University)
#2Edward Chung Yern Wang (Cardiff University)H-Index: 34
Last. James A. Traherne (University of Cambridge)H-Index: 23
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Molluscum contagiosum virus (MCV) is a common cause of benign skin lesions in young children and currently the only endemic human poxvirus. Following the infection of primary keratinocytes in the epidermis, MCV induces the proliferation of infected cells and this results in the production of wart-like growths. Full productive infection is observed only after the infected cells differentiate. During this prolonged replication cycle the virus must avoid elimination by the host immune system. We th...
#1Robert Hollingworth (University of Birmingham)H-Index: 5
#2Grant S. Stewart (University of Birmingham)H-Index: 32
Last. Roger J. A. Grand (University of Birmingham)H-Index: 29
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Gammaherpesviruses establish lifelong latent infection in B lymphocytes and are the causative agent of several B-cell malignancies and lymphoproliferative disorders. While a quiescent latent infection allows these pathogens to evade immune detection, initiation of an alternative lifecycle stage, known as lytic replication, is an essential step in the production and dissemination of infectious progeny. Although cessation of cellular proliferation is an eventual consequence of lytic induction, exa...
#1Kikue Saika (Saitama Medical University)H-Index: 1
#2Masahiko Kato (Sysmex Corporation)
Last. Masaaki Kawano (Saitama Medical University)H-Index: 14
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Simian virus 40 (SV40) is a monkey polyomavirus. The capsid structure is icosahedral and comprises VP1 units that measure 45 nm in diameter. Five SV40 VP1 molecules form one pentamer subunit, and a single icosahedral subunit comprises 72 pentamers; a single SV40 VP1 capsid comprises 360 SV40 VP1 molecules. In a previous study, we showed that an influenza A virus matrix protein 1 (M1) CTL epitope inserted within SV40 virus-like particles (VLPs) induced cytotoxic T lymphocytes (CTLs) without the n...
#1Manabu Nemoto (Japan Racing Association)H-Index: 15
#2Hidekazu Niwa (Japan Racing Association)H-Index: 9
Last. Minoru Ohta (Japan Racing Association)H-Index: 7
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A rare genotype G13P[18] group A rotavirus (RVA/Horse-tc/JPN/MK9/2019/G13P[18]) was isolated from a diarrhoeic foal for the first time in 28 years. The genotype constellation of the virus was assigned to G13-P[18]-I6-R9-C9-M6-A6-N9-T12-E14-H11 and was the same as that of the first isolated strain, RVA/Horse-tc/GBR/L338/1991/G13P[18]. Phylogenetic analysis suggests that the virus is related to RVA/Horse-tc/GBR/L338/1991/G13P[18] and is distant from typical equine rotaviruses of the G3P[12] and G1...
#1Saori Fukuda (Fujita Health University)H-Index: 3
#2Riona Hatazawa (Fujita Health University)H-Index: 1
Last. Satoshi Komoto (Fujita Health University)H-Index: 15
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Reassortment is an important mechanism in the evolution of group A rotaviruses (RVAs), yielding viruses with novel genetic and phenotypic traits. The classical methods for generating RVA reassortants with the desired genetic combinations are laborious and time-consuming because of the screening and selection processes required to isolate a desired reassortant. Taking advantage of a recently developed RVA reverse genetics system based on just 11 cloned cDNAs encoding the RVA genome (11 plasmid-on...
#1Rodolfo Gamaliel Avila-Bonilla (IPN: Instituto Politécnico Nacional)H-Index: 1
#2Martha Yocupicio-Monroy (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 6
Last. Juan Santiago Salas-Benito (IPN: Instituto Politécnico Nacional)H-Index: 12
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Dengue virus (DENV) is an important flavivirus that is transmitted to humans by Aedes mosquitoes, where it can establish a persistent infection underlying vertical and horizontal transmission. However, the exact mechanism of persistent DENV infection is not well understood. Recently miR-927 was found to be upregulated in C6/36-HT cells at 57 weeks of persistent infection (C6-L57), suggesting its participation during this type of infection. The aim of this study was to determine the role of miR-9...
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Molecular biology