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Journal of General Virology
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2.81
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16459
Papers 16521
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#1Jolene Yin Ling Fu (UM: University of Malaya)
#2Chong Long Chua (UM: University of Malaya)H-Index: 6
Last.I-Ching Sam (UM: University of Malaya)H-Index: 23
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Chikungunya virus (CHIKV) has caused large-scale epidemics of fever, rash and arthritis since 2004. This unprecedented re-emergence has been associated with mutations in genes encoding structural envelope proteins, providing increased fitness in the secondary vector Aedes albopictus. In the 2008–2013 CHIKV outbreaks across Southeast Asia, an R82S mutation in non-structural protein 4 (nsP4) emerged early in Malaysia or Singapore and quickly became predominant. To determine whether this nsP4-R82S ...
#1Helen E. Farrell (UQ: University of Queensland)H-Index: 26
#2Kimberley Bruce (UQ: University of Queensland)H-Index: 4
Last.Philip G. Stevenson (UQ: University of Queensland)H-Index: 37
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Cytomegaloviruses (CMVs) use myeloid cells to move within their hosts. Murine CMV (MCMV) colonizes the salivary glands for long-term shedding, and reaches them via CD11c+ infected cells. A need to recruit patrolling monocytes for systemic spread has been proposed, based on poor salivary gland infection in fractalkine receptor (CX3CR1)-deficient mice. We found no significant CX3CR1 dependence of salivary gland infection. CCL2 and the viral m131/m129 chemokine homologue were also redundant for acu...
#1B. K. Rima ('QUB': Queen's University Belfast)H-Index: 14
Last.Benhur Lee (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 52
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The family Paramyxoviridae consists of large enveloped RNA viruses infecting mammals, birds, reptiles and fish. Many paramyxoviruses are host-specific and several, such as measles virus, mumps virus, Nipah virus, Hendra virus and several parainfluenza viruses, are pathogenic for humans. The transmission of paramyxoviruses is horizontal, mainly through airborne routes; no vectors are known. This is a summary of the current International Committee on Taxonomy of Viruses (ICTV) Report on the family...
#1Arushi Vats (International Centre for Genetic Engineering and Biotechnology)
#2Jayashree Thatte (International Centre for Genetic Engineering and Biotechnology)H-Index: 1
Last.Lawrence Banks (International Centre for Genetic Engineering and Biotechnology)H-Index: 54
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The high-risk Human Papillomavirus (HPV) E6 oncoprotein is known to contribute to human malignancy by targeting several of its cellular substrates through the ubiquitin-mediated degradation pathway. Previous studies have revealed that E6 interacts with the E6AP ubiquitin-protein ligase and directs its ubiquitylation activity toward several specific cellular proteins, one of the most important of which is p53. However, the role of E6AP in the degradation of many other E6 substrates is still ambig...
#1Firzan Nainu (Hasanuddin University)
#2Alice Trenerry (UQ: University of Queensland)
Last.Karyn N. Johnson (UQ: University of Queensland)H-Index: 25
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Vector-borne viral diseases pose significant risks to human health. To control the transmission of these viruses, a number of approaches are required. The ability of the intracellular bacteria Wolbachia to limit viral accumulation and transmission in some arthropod hosts, highlights its potential as a biocontrol agent. Whilst Wolbachia can reduce the transmission of several epidemiologically important viruses, protection is not consistent amongst all insects, viruses and strains of Wolbachia , w...
#1Hyerin Jeong (PNU: Pusan National University)H-Index: 1
#2Sungkyung Cha (PNU: Pusan National University)
Last.Kyung Lib Jang (PNU: Pusan National University)H-Index: 22
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Proteasomal activator 28 gamma (PA28γ) is frequently overexpressed in hepatocellular carcinoma; however, its underlying mechanism and role in hepatitis B virus (HBV) replication are largely unknown. Here, we found that HBV X protein (HBx) natural variants containing Ser-101 instead of Pro-101 increase reactive oxygen species levels in the mitochondria and activate the ataxia telangiectasia mutated/checkpoint kinase 2 pathway in the nucleus, resulting in the phosphorylation of p53 at Ser-15 and S...
#1Shaohua Lei (VT: Virginia Tech)
#2Erica Twitchell (VT: Virginia Tech)H-Index: 6
Last.Sylvia Becker-Dreps (UNC: University of North Carolina at Chapel Hill)H-Index: 12
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#1Juan Ledesma (NIHR: National Institute for Health Research)H-Index: 1
#2David Williams (PHE: Public Health England)
Last.Samreen Ijaz (NIHR: National Institute for Health Research)H-Index: 34
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Hepatitis E virus (HEV) is a zoonotic infection, with consumption of processed pork products thought to be the major route of transmission in England. The clinical features of HEV infection range from asymptomatic infection to mild hepatitis to fulminant liver failure. Persistent, chronic hepatitis is increasingly recognized in immunocompromised patients. Infection via HEV-containing blood components and organs has been reported and measures to reduce this transmission risk were introduced into ...
#1Azaibi Tamin (National Center for Immunization and Respiratory Diseases)H-Index: 21
#2Krista Queen (National Center for Immunization and Respiratory Diseases)H-Index: 1
Last.Shifaq Kamili (National Center for Immunization and Respiratory Diseases)H-Index: 1
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Middle East respiratory syndrome (MERS) is a viral respiratory illness first reported in Saudi Arabia in September 2012 caused by the human coronavirus (CoV), MERS-CoV. Using full-genome sequencing and phylogenetic analysis, scientists have identified three clades and multiple lineages of MERS-CoV in humans and the zoonotic host, dromedary camels. In this study, we have characterized eight MERS-CoV isolates collected from patients in Saudi Arabia in 2015. We have performed full-genome sequencing...
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