Original paper
In vivo continuous evolution of metabolic pathways for chemical production
Abstract
Microorganisms have long been used as chemical plant to convert simple substrates into complex molecules. Various metabolic pathways have been optimised over the past few decades, but the progresses were limited due to our finite knowledge on metabolism. Evolution is a knowledge-free genetic randomisation approach, employed to improve the chemical production in microbial cell factories. However, evolution of large, complex pathway was a great...
Paper Details
Title
In vivo continuous evolution of metabolic pathways for chemical production
Published Date
May 14, 2019
Journal
Volume
18
Issue
1
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Notes
History