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Zheng Lin Tan
Tsinghua University
2Publications
Publications 2
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#1Zheng Lin Tan (THU: Tsinghua University)
#2Xiang Zheng (THU: Tsinghua University)H-Index: 3
Last.Chong Zhang (THU: Tsinghua University)H-Index: 24
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Microorganisms have long been used as chemical plant to convert simple substrates into complex molecules. Various metabolic pathways have been optimised over the past few decades, but the progresses were limited due to our finite knowledge on metabolism. Evolution is a knowledge-free genetic randomisation approach, employed to improve the chemical production in microbial cell factories. However, evolution of large, complex pathway was a great challenge. The invention of continuous culturing syst...
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#1Chunxuan Ma (THU: Tsinghua University)
Last.Chong Zhang (THU: Tsinghua University)H-Index: 24
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Xylanases have useful applications in a wide range of industries. In this regard, Pichia pastoris has become one of the most attractive host platforms for large-scale production of xylanases. However, genomic engineering is still required for overexpression and efficient secretion. In this paper, we applied droplet-based method to screen directed evolved extracellular xylanase producing P. pastoris strain. Xylanase-producing P. pastoris cells were encapsulated in gel microdroplets with a fluorog...
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