Original paper
Anephrogenic phenotype induced by SALL1 gene knockout in pigs
Abstract
To combat organ shortage in transplantation medicine, a novel strategy has been proposed to generate human organs from exogenous pluripotent stem cells utilizing the developmental mechanisms of pig embryos/foetuses. Genetically modified pigs missing specific organs are key elements in this strategy. In this study, we demonstrate the feasibility of using a genome-editing approach to generate anephrogenic foetuses in a genetically engineered pig...
Paper Details
Title
Anephrogenic phenotype induced by SALL1 gene knockout in pigs
Published Date
May 29, 2019
Journal
Volume
9
Issue
1
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Notes
History