Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes

The epitranscriptome comprises more than 100 forms of RNA modifications. Of these, N6-methyladenosine (m6A) is the most abundant form of RNA methylation, with roles in modulating mRNA transcript processing and regulation. The aims of the study were to examine changes in m6A RNA methylation in A549 lung epithelial cells in response to environmental toxicants, and differential gene expression of m6A modulator genes (‘readers’, ‘writers’ and...