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Hyang-Min Byun
Newcastle University
Molecular biologyDNA methylationMethylationEpigeneticsBiology
107Publications
31H-index
3,285Citations
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Publications 114
Newest
#1Amit Sharma (University Hospital Bonn)H-Index: 3
#2Simon T. Schaefer (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. Ullrich Wüllner (German Center for Neurodegenerative Diseases)H-Index: 6
view all 5 authors...
Purpose: Mitochondrial dysfunction has long been considered in the pathogenesis of Parkinson's disease (PD). This is evident from the presence of mitochondrial DNA deletions in substantia nigra neurons and respiratory chain abnormalities in the skeletal muscle of PD patients. However, the contributing factors that potentially cause oxidative stress in PD are still elusive. To a certain extent, the identification of acquired changes in circulating mitochondrial DNA (mtDNA) content in blood sample...
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Last. Hyang-Min ByunH-Index: 31
view all 7 authors...
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#1Timothy M. BarrowH-Index: 5
#2Nicole Wong DooH-Index: 4
Last. Hyang-Min ByunH-Index: 31
view all 7 authors...
Retrotransposons such as LINE-1 and Alu comprise >25% of the human genome. While global hypomethylation of these elements has been widely reported in solid tumours, their epigenetic dysregulation is yet to be characterised in chronic lymphocytic leukaemia, and there has been scant consideration of their evolutionary history that mediates sensitivity to hypomethylation. Here, we developed an approach for locus- and evolutionary subfamily-specific analysis of retrotransposons using the Illumina In...
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#1Akin Cayir (Newcastle University)H-Index: 3
#2Timothy M. Barrow (University of Sunderland)H-Index: 5
Last. Hyang-Min Byun (Newcastle University)H-Index: 31
view all 4 authors...
The epitranscriptome comprises more than 100 forms of RNA modifications. Of these, N6-methyladenosine (m6A) is the most abundant form of RNA methylation, with roles in modulating mRNA transcript processing and regulation. The aims of the study were to examine changes in m6A RNA methylation in A549 lung epithelial cells in response to environmental toxicants, and differential gene expression of m6A modulator genes ('readers', 'writers' and 'erasers') in human subjects exposed to particulate matte...
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#1Hyang-Min Byun (Newcastle University)H-Index: 31
1 CitationsSource
#1Timothy M. Barrow (University of Sunderland)H-Index: 5
#2Cheng Peng (Harvard University)H-Index: 4
Last. Hyang-Min Byun (Newcastle University)H-Index: 31
view all 11 authors...
Purpose Psychosocial stress, including bereavement and work-related stress, is associated with the risk of breast cancer. However, it is unknown whether it may also be linked with increased risk of benign breast disease (BBD).
2 CitationsSource
#1Akin CayirH-Index: 3
#2Timothy M. BarrowH-Index: 5
Last. Hyang-Min ByunH-Index: 31
view all 11 authors...
OBJECTIVES: We investigated the association between occupational noise exposure and the risk of elevated blood pressure and hypertension by stage in young adults. METHODS: We utilized 124,286 young adults (18-40 years) from the Project ELEFANT study. We categorized occupational noise exposure as high (75 dBA noise exposure for more than 4 hours per day) or low, and measured blood pressure (mmHg) and categorized participants by hypertension stage (normal, elevated, Stage 1, Stage 2). We applied a...
1 CitationsSource
#1Liqiong Guo (Tianjin Medical University)H-Index: 5
#2Cheng Peng (Harvard University)H-Index: 4
Last. Hyang-Min Byun (Newcastle University)H-Index: 31
view all 13 authors...
Early and late age at menarche are associated with risk of hypertension, but little is known whether modifiable lifestyle can reduce this risk. Our study leverages 60,135 healthy young Chinese women from the Environmental and LifEstyle FActors iN metabolic health throughout life-course Trajectories (ELEFANT) study. Menarche age and lifestyle factors were assessed by self-reported questionnaires and hypertension was diagnosed by physicians. We estimated the odds ratios (ORs) of hypertension assoc...
1 CitationsSource
#1Chanachai Sae-Lee (MU: Mahidol University)H-Index: 1
#2Sarah Corsi (Newcastle University)H-Index: 1
Last. Hyang-Min Byun (Newcastle University)H-Index: 31
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Scope: Alterations in DNA methylation patterns are correlated with aging, environmental exposures and disease pathophysiology; the possibility of reverting or preventing these processes through dietary intervention is gaining momentum. In particular, methyl donors that provide S-adenosyl-methionine for one-carbon metabolism and polyphenols such as flavanols that inhibit the activity of DNA methyltransferases (DNMTs) could be key modifiers of epigenetic patterns. Methods and results: We assessed ...
1 CitationsSource
#1Hui XuH-Index: 1
#2Peng-hui LiH-Index: 3
Last. Hyang-Min ByunH-Index: 31
view all 11 authors...
BACKGROUND: The menstrual cycle is regulated by reproductive hormones such as estrogen which has been implicated in the pathogenesis of hypertension and is associated with obesity. However, to date there has scant study of hypertension in relation to menstrual characteristics and abnormalities. We hypothesize that adverse menstrual characteristics are associated with an increase the prevalence of hypertension and that this relationship is exacerbated by obesity. METHODS: Our study leverages 178,...
2 CitationsSource
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