Mitohormesis Primes Tumor Invasion and Metastasis
Abstract
Moderate mitochondrial stress can lead to persistent activation of cytoprotective mechanisms – a phenomenon termed mitohormesis. Here, we show that mitohormesis primes a subpopulation of cancer cells to basally upregulate mitochondrial stress responses, such as the mitochondrial unfolded protein response (UPRmt) providing an adaptive metastatic advantage. In this subpopulation, UPRmt activation persists in the absence of stress, resulting in...
Paper Details
Title
Mitohormesis Primes Tumor Invasion and Metastasis
Published Date
May 1, 2019
Journal
Volume
27
Issue
8
Pages
2292 - 2303.e6
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