Systemic low-grade inflammation and subsequent depressive symptoms: Is there a mediating role of physical activity?

Systemic low-grade inflammation has been associated with the onset of depression, but the exact mechanisms underlying this relationship remain elusive. This study examined whether physical activity (PA) explained the association between elevated serum levels of inflammatory markers and subsequent depressive symptoms. Prospective cohort design. The sample consisted of 3809 non-depressed men and women (aged 50+) recruited from the English...