Brain Behavior and Immunity
Papers 5900
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#1Anna Escrig (Autonomous University of Barcelona)H-Index: 1
#2Carla Canal (Autonomous University of Barcelona)
Last.Juan Hidalgo (Autonomous University of Barcelona)H-Index: 53
view all 12 authors...
Abstract Alzheimer’s disease (AD) is the most commonly diagnosed dementia but its underlying pathological mechanisms still unclear. Neuroinflammation and secretion of cytokines such as interleukin-6 (IL-6) accompany the main hallmarks of the disease: amyloid plaques and neurofibrillary tangles. In this study, we analyzed the role of IL-6 trans-signaling in two mouse models of AD, Tg2576 and 3xTg-AD mice. The inhibition of IL-6 trans-signaling partially rescued the AD-induced mortality in females...
#1Jeffrey G. Snodgrass (CSU: Colorado State University)H-Index: 15
#2Michael G. Lacy (CSU: Colorado State University)H-Index: 17
Last.Steven W. Cole (UCLA: University of California, Los Angeles)H-Index: 79
view all 7 authors...
Abstract Previous research has identified a link between experiencing life as meaningful and purposeful—what is referred to as “eudaimonia”—and reduced expression of a stress-induced gene profile known as the “conserved transcriptional response to adversity” (CTRA). In the current study, we examine whether similar links between eudaimonic well-being and CTRA reduction occur in a sample of 56 individuals with a particularly strong engagement with virtual worlds: avid online videogame players. Res...
#1H.M. Kowash (MAHSC: Manchester Academic Health Science Centre)
#2H.G. Potter (MAHSC: Manchester Academic Health Science Centre)
Last.Jocelyn D. Glazier (MAHSC: Manchester Academic Health Science Centre)H-Index: 34
view all 8 authors...
Abstract The viral mimetic polyinosinic:polycytidylic acid (poly(I:C)) is increasingly used to induce maternal immune activation (mIA) to model neurodevelopmental disorders (NDDs). Robust and reproducible phenotypes across studies are essential for the generation of models that will enhance our understanding of NDDs and enable the development of improved therapeutic strategies. However, differences in mIA-induced phenotypes using poly(I:C) have been widely observed, and this has prompted the rep...
#1Zach M. LaMacchia (SUNY: State University of New York System)H-Index: 1
#2Robert N. SpenglerH-Index: 24
Last.Tracey A. Ignatowski (SUNY: State University of New York System)H-Index: 22
view all 8 authors...
Abstract Neuropathic pain is chronic pain that follows nerve injury, mediated in the brain by elevated levels of the inflammatory protein tumor necrosis factor-alpha (TNF). We have shown that peripheral nerve injury increases TNF in the hippocampus/pain perception region, which regulates neuropathic pain symptoms. In this study we assessed pain sensation and perception subsequent to specific targeting of brain-TNF (via TNF antibody) administered through a novel subcutaneous perispinal route. Neu...
1 CitationsSource
#1Leonie J.T. Balter (University of Birmingham)H-Index: 1
#2Jane E. Raymond (University of Birmingham)H-Index: 35
Last.Jos A. Bosch (UvA: University of Amsterdam)H-Index: 36
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Abstract The established link between loneliness and poor health outcomes may stem from aberrant inflammatory regulation. The present study tested whether loneliness predicted the inflammatory response to a standardised in vivo immune challenge. Using a within-subjects double blind placebo-controlled design, 40 healthy men (mean age = 25, SD = 5) received a Salmonella Typhi vaccination (0.025 mg; Typhim Vi, Sanofi Pasteur, UK) and placebo (saline) on two separate occasions. Loneliness was assess...
#1Zinah Zamil Al-Ghezi (USC: University of South Carolina)H-Index: 1
#2Philip B. Busbee (USC: University of South Carolina)H-Index: 4
Last.Mitzi Nagarkatti (USC: University of South Carolina)H-Index: 46
view all 5 authors...
Abstract Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is used as a drug to treat muscle spasticity in patients with Multiple Sclerosis (MS). Because these cannabinoids can also suppress inflammation, it is unclear whether such patients benefit from suppression of neuroinflammation and if so, what is the mechanism through which cannabinoids act. In the currently study, we used a murine model of MS, experimental autoimmune en...
1 CitationsSource
#1William B. Malarkey (The Ohio State University Wexner Medical Center)
#1Erin Cvejic (UNSW: University of New South Wales)H-Index: 8
#2Hui Li (Kirby Institute)H-Index: 5
Last.Ute Vollmer-Conna (UNSW: University of New South Wales)H-Index: 24
view all 6 authors...
Abstract Background Substantial heterogeneity exists in both the severity of symptoms experienced as part of the sickness response to naturally-occurring infections, and the time taken for individuals to recover from these symptoms. Although contributing immunological and genetic factors have been previously been explored, less is known about the role of individual psychological and psychosocial factors, which may modulate the host immune response, or contribute independently, to symptom severit...
#1Wen-Jun Su ('SMMU': Second Military Medical University)H-Index: 8
#2Zhi-Yong Cao ('SMMU': Second Military Medical University)H-Index: 1
Last.Chun-Lei Jiang ('SMMU': Second Military Medical University)H-Index: 17
view all 3 authors...
#1Senthil Kumaran Satyanarayanan (PRC: China Medical University (PRC))H-Index: 2
#2Yin-Hwa Shih (PRC: China Medical University (PRC))
Last.Kuan-Pin Su (PRC: China Medical University (PRC))H-Index: 28
view all 8 authors...
Abstract Chronic pain and depression are often comorbid exhibiting common clinical presentations and biological connections related to central nervous system sensitization. Epigenetic regulation of gene expression in the brain plays a crucial role in response to long-lasting stress and chronic pain, and microRNA imbalance in the prefrontal cortex (PFC) might be involved in central sensitization. Male Sprague Dawley rats were subjected to unpredictable chronic mild stress (UCMS) and spared nerve ...
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