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Dorina Cadar
University College London
Longitudinal studyDementiaCognitive declineMedicineGerontology
100Publications
10H-index
308Citations
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Publications 98
Newest
#1Yixuan Ma (UCL: University College London)
#2Olesya Ajnakina (UCL: University College London)H-Index: 12
Last. Dorina Cadar (UCL: University College London)H-Index: 10
view all 4 authors...
BACKGROUND Several risk factors contribute to dementia, but the role of obesity remains unclear. This study investigated whether increased body weight or central obesity were associated with a higher risk of developing dementia in a representative sample of older English adults. METHODS We studied 6582 participants from the English Longitudinal Study of Ageing (ELSA) who were aged ≥50 years and were dementia-free at baseline, that being either wave 1 (2002-2003) for study members who started at ...
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#1Dorina Cadar (UCL: University College London)H-Index: 10
#2Annie Robitaille (Université du Québec)
Last. Graciela Muniz-Terrera (Edin.: University of Edinburgh)H-Index: 12
view all 5 authors...
: The current study investigates the heterogeneity of cognitive trajectories at the end of life by assigning individuals into groups according to their cognitive trajectories prior to death. It also examines the role of childhood intelligence and education on these trajectories and group membership. Participants were drawn from the Lothian Birth Cohort of 1921 (LBC1921), a longitudinal study of individuals with a mean age of 79 years at study entry, and observed up to a maximum of five times to ...
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#1Philipp Frank (UCL: University College London)H-Index: 1
#2Olesya Ajnakina (UCL: University College London)H-Index: 12
Last. Dorina Cadar (UCL: University College London)H-Index: 10
view all 4 authors...
Genetic susceptibility to depression has been established using polygenic scores, but the underlying mechanisms and the potentially differential effects of polygenic scores on specific types of depressive symptoms remain unknown. This study examined whether systemic low-grade inflammation mediated the association between polygenic scores for depressive symptomatology (DS-PGS) and subsequent somatic versus cognitive-affective depressive symptoms. The sample consisted of 3510 men and women (aged 5...
1 CitationsSource
#1Pamela Almeida-Meza (UCL: University College London)H-Index: 1
#2Andrew Steptoe (UCL: University College London)H-Index: 117
Last. Dorina Cadar (UCL: University College London)H-Index: 10
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BACKGROUND: In the current climate of an ageing population, it is imperative to identify preventive measures for dementia. AIMS: We implemented a multifaceted index of cognitive reserve markers and investigated dementia incidence over 15 years of follow-up in a representative sample of the English population. METHOD: Data were 12 280 participants aged >/=50 years from the English Longitudinal Study of Ageing, free from dementia at their baseline assessments during wave 1 (2002-2003), 3 (2006-200...
1 CitationsSource
#1Olesya Ajnakina (UCL: University College London)H-Index: 12
#1Olesya Ajnakina (UCL: University College London)
Last. Andrew Steptoe (UCL: University College London)H-Index: 117
view all 3 authors...
OBJECTIVES: Identifying the interplay between socioeconomic markers (education and financial resources) and polygenetic predisposition influencing the time of dementia and the diagnosis of clinical Alzheimer's disease (AD) dementia is of central relevance for preventive strategies. DESIGN: Prospective cohort design. SETTING: The English Longitudinal Study of Aging is a household survey data set of a representative sample. PARTICIPANTS: A total of 7,039 individuals aged 50 years and older partici...
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#1Christian von Wagner (UCL: University College London)H-Index: 30
#2Dorina Cadar (UCL: University College London)H-Index: 10
Last. Sandro Stoffel (UCL: University College London)H-Index: 4
view all 10 authors...
ObjectivesType 2 diabetes has been identified as a risk factor for colorectal cancer, but little is known about whether it influences participation in colorectal cancer screening programmes. This s...
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#1Marta Jackowska (University of Roehampton)H-Index: 10
#2Dorina Cadar (UCL: University College London)H-Index: 10
Abstract Suboptimal sleep patterns predict poorer cognitive function in older adults and induce inflammatory responses. Inflammation could also adversely affect cognitive function. This study explored whether systemic inflammation may be one biological mechanism through which sleep influences cognitive performance. Participants were 4877 men and women from the English Longitudinal Study of Ageing who were followed-up for 8 years starting at wave 4 (2008-09), through wave 6 (2012-13), and until w...
2 CitationsSource
#1Ann E M Liljas (KI: Karolinska Institutet)H-Index: 9
#2Amy Jones (UCL: University College London)H-Index: 1
Last. Camille Lassale (UCL: University College London)H-Index: 21
view all 5 authors...
Importance Sensory acuity tends to decrease with age, but little is known about the relationship between having multiple sensory impairments and well-being in later life. Objective To examine associations between concurrent multisensory impairments and aspects of well-being and mental health, namely quality of life and depressive symptoms. Design, Setting, and Participants Cross-sectional analysis of participants in the English Longitudinal Study of Aging wave 8 (May 2016 to June 2017). This is ...
1 CitationsSource
#1Camille Lassale (UCL: University College London)H-Index: 21
#2Pierluigi Vullo (UCL: University College London)H-Index: 1
Last. Paola Zaninotto (UCL: University College London)H-Index: 23
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Abstract Background Hearing impairment is common at an older age and has considerable social, health and economic implications. With an increase in the ageing population, there is a need to identify modifiable risk factors for hearing impairment. A shared aetiology with cardiovascular disease (CVD) has been advanced as CVD risk factors (e.g. obesity, type 2 diabetes) are associated with a greater risk of hearing impairment. Moreover, low-grade inflammation is implicated in the aetiology of CVD. ...
1 CitationsSource
#1Daisy Fancourt (UCL: University College London)H-Index: 11
#2Andrew Steptoe (UCL: University College London)H-Index: 117
Last. Dorina Cadar (UCL: University College London)H-Index: 10
view all 3 authors...
Background There is increasing interest in the potential health benefits of referring older adults to engage in community leisure activities (‘social prescribing’) to help promote healthy cognitive ageing. However, it remains unclear whether beneficial effects of community engagement are independent of the well-known protective effects of broader structural, functional and subjective social factors. Methods We analysed data from 9550 adults aged 50+ from the English Longitudinal Study of Ageing,...
1 CitationsSource
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