Original paper
RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas
Abstract
Glioblastomas strongly invade the brain by infiltrating into the white matter along myelinated nerve fiber tracts even though the myelin protein Nogo-A prevents cell migration by activating inhibitory RhoA signaling. The mechanisms behind this long-known phenomenon remained elusive so far, precluding a targeted therapeutic intervention. This study demonstrates that the prevalent activation of AKT in gliomas increases the ER protein-folding...
Paper Details
Title
RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas
Published Date
May 6, 2019
Journal
Volume
138
Issue
2
Pages
275 - 293
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Notes
History