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Acta Neuropathologica
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18.17
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9347
Papers 9382
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Published on 2019in Acta Neuropathologica18.17
Ito Kawakami3
Estimated H-index: 3
,
Tetsuaki Arai38
Estimated H-index: 38
,
Masato Hasegawa53
Estimated H-index: 53
Transactive response DNA-binding protein 43 kDa (TDP-43) was identified as a major disease-associated component in the brain of patients with amyotrophic lateral sclerosis (ALS), as well as the largest subset of patients with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), which characteristically exhibits cytoplasmic inclusions that are positive for ubiquitin but negative for tau and α-synuclein. TDP-43 pathology occurs in distinct brain regions, involves disparate bra...
Published on 2019in Acta Neuropathologica18.17
Stephen Moore1
Estimated H-index: 1
,
Eric Alsop1
Estimated H-index: 1
+ 7 AuthorsJeannie Chew12
Estimated H-index: 12
Published on Sep 21, 2019in Acta Neuropathologica18.17
Eun-Joo Kim (PNU: Pusan National University), Ji-Hye L. Hwang1
Estimated H-index: 1
(UCSF: University of California, San Francisco)
+ 13 AuthorsLea T. Grinberg40
Estimated H-index: 40
(UCSF: University of California, San Francisco)
Common neurodegenerative diseases feature progressive accumulation of disease-specific protein aggregates in selectively vulnerable brain regions. Increasing experimental evidence suggests that misfolded disease proteins exhibit prion-like properties, including the ability to seed corruptive templating and self-propagation along axons. Direct evidence for transneuronal spread in patients, however, remains limited. To test predictions made by the transneuronal spread hypothesis in human tissues, ...
Published on Sep 18, 2019in Acta Neuropathologica18.17
Conceição Bettencourt18
Estimated H-index: 18
,
Sandrine C. Foti2
Estimated H-index: 2
+ 8 AuthorsEmmanuelle Viré
Multiple system atrophy (MSA) is a fatal late-onset neurodegenerative disease. Although presenting with distinct pathological hallmarks, which in MSA consist of glial cytoplasmic inclusions (GCIs) containing fibrillar α-synuclein in oligodendrocytes, both MSA and Parkinson’s disease are α-synucleinopathies. Pathologically, MSA can be categorized into striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) or mixed subtypes. Despite extensive research, the regional vulnerability of ...
Published on Sep 12, 2019in Acta Neuropathologica18.17
Emily A. Sloan (UC: University of California), Tabitha Cooney (Children's Hospital Oakland)+ 42 AuthorsSabine Mueller25
Estimated H-index: 25
(UC: University of California)
Published on Sep 9, 2019in Acta Neuropathologica18.17
Ian R. Mackenzie78
Estimated H-index: 78
(UBC: University of British Columbia),
Manuela Neumann6
Estimated H-index: 6
(German Center for Neurodegenerative Diseases)
Frontotemporal lobar degeneration with TDP-43 immunoreactive (TDP-ir) inclusions (FTLD-TDP) is sub-classified based on the pattern of neocortical pathology, with each subtype showing clinical and genetic correlations. Recent studies indicate that accurate subtyping of cases may be important to help identify genetic risk factors and develop biomarkers. Although most FTLD-TDP cases are easily classified, some do not match well to one of the existing subtypes. In particular, cases with the C9orf72 ...
Published on Sep 7, 2019in Acta Neuropathologica18.17
Anna Raunio3
Estimated H-index: 3
(UH: University of Helsinki),
Karri Kaivola1
Estimated H-index: 1
(UH: University of Helsinki)
+ 6 AuthorsLiisa Myllykangas22
Estimated H-index: 22
(UH: University of Helsinki)
According to a generally accepted concept Lewy-related pathology (LRP) follows hierarchical caudo-rostral progression. LRP is also frequently present concomitantly with Alzheimer’s disease (AD), and it has been hypothesized that AD-associated LRP forms a distinct type of α-synucleinopathy, where LRP originates in the amygdala. The frequency of distinct forms of LRP progression types has not been studied in a population-based setting. We investigated the distribution and progression of LRP and it...
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